ACTH receptor

MC2R
Identifiers
Aliases	MC2R, ACTHR, melanocortin 2 receptor
External IDs	OMIM: 607397; MGI: 96928; HomoloGene: 444; GeneCards: MC2R; OMA:MC2R - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	13,915,707 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	68,562,391 bp
RNA expression pattern
	Top expressed in
	right adrenal gland; ; left adrenal gland; ; right adrenal cortex; ; left adrenal cortex; ; metanephros; ; pituitary gland; ; anterior pituitary; ; appendix; ; testicle; ; right testis;
	Top expressed in
	adrenal gland; ; white adipose tissue; ; lactiferous gland; ; adrenal cortex; ; brown adipose tissue; ; subcutaneous adipose tissue; ; muscle of thigh; ; ankle; ; striated muscle tissue; ; tibiofemoral joint;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	melanocortin receptor activity; protein binding; G protein-coupled receptor activity; corticotropin receptor activity; signal transducer activity;
Cellular component	cytoplasm; integral component of membrane; plasma membrane; integral component of plasma membrane; membrane;
Biological process	G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; signal transduction; placenta development; neuropeptide signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	4158
	17200
	ENSG00000185231
	ENSMUSG00000045569
	Q01718
	Q64326
	NM_001291911; NM_000529
	NM_001271716; NM_001271717; NM_008560; NM_001301372
	NP_000520; NP_001278840
	NP_001258645; NP_001258646; NP_001288301; NP_032586
	Wikidata
View/Edit Human	View/Edit Mouse

The adrenocorticotropic hormone receptor or ACTH receptor also known as the melanocortin receptor 2 or MC₂ receptor is a type of melanocortin receptor (type 2) which is specific for ACTH.^[5] A G protein–coupled receptor located on the external cell plasma membrane, it is coupled to G_αs and upregulates levels of cAMP by activating adenylyl cyclase.^[6]^[7]^[8] The ACTH receptor plays a role in immune function and glucose metabolism.^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000185231 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000045569 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Beuschlein F, Fassnacht M, Klink A, Allolio B, Reincke M (March 2001). "ACTH-receptor expression, regulation and role in adrenocortial tumor formation". European Journal of Endocrinology. 144 (3): 199–206. doi:10.1530/eje.0.1440199. PMID 11248736.
^ Fridmanis D, Roga A, Klovins J (6 February 2017). "ACTH Receptor (MC2R) Specificity: What Do We Know About Underlying Molecular Mechanisms?". Frontiers in Endocrinology. 8: 13. doi:10.3389/fendo.2017.00013. PMC 5292628. PMID 28220105.
^ Hanukoglu I, Feuchtwanger R, Hanukoglu A (November 1990). "Mechanism of corticotropin and cAMP induction of mitochondrial cytochrome P450 system enzymes in adrenal cortex cells" (PDF). The Journal of Biological Chemistry. 265 (33): 20602–8. doi:10.1016/S0021-9258(17)30545-8. PMID 2173715.
^ Elias LL, Clark AJ (October 2000). "The expression of the ACTH receptor". Brazilian Journal of Medical and Biological Research. 33 (10): 1245–8. doi:10.1590/S0100-879X2000001000015. PMID 11004726.
^ "ACTH - Clinical: Adrenocorticotropic Hormone (ACTH), Plasma". www.mayomedicallaboratories.com. Retrieved 2016-10-25.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000185231 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000045569 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11248736-5] Beuschlein F, Fassnacht M, Klink A, Allolio B, Reincke M (March 2001). "ACTH-receptor expression, regulation and role in adrenocortial tumor formation". European Journal of Endocrinology. 144 (3): 199–206. doi:10.1530/eje.0.1440199. PMID 11248736.

[fridmanis2017-6] Fridmanis D, Roga A, Klovins J (6 February 2017). "ACTH Receptor (MC2R) Specificity: What Do We Know About Underlying Molecular Mechanisms?". Frontiers in Endocrinology. 8: 13. doi:10.3389/fendo.2017.00013. PMC 5292628. PMID 28220105.

[pmid2173715-7] Hanukoglu I, Feuchtwanger R, Hanukoglu A (November 1990). "Mechanism of corticotropin and cAMP induction of mitochondrial cytochrome P450 system enzymes in adrenal cortex cells" (PDF). The Journal of Biological Chemistry. 265 (33): 20602–8. doi:10.1016/S0021-9258(17)30545-8. PMID 2173715.

[pmid11004726-8] Elias LL, Clark AJ (October 2000). "The expression of the ACTH receptor". Brazilian Journal of Medical and Biological Research. 33 (10): 1245–8. doi:10.1590/S0100-879X2000001000015. PMID 11004726.

[9] "ACTH - Clinical: Adrenocorticotropic Hormone (ACTH), Plasma". www.mayomedicallaboratories.com. Retrieved 2016-10-25.

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