ADAM17

ADAM17
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BKC, 1ZXC, 2A8H, 2DDF, 2FV5, 2FV9, 2I47, 2M2F, 2OI0, 3B92, 3CKI, 3E8R, 3EDZ, 3EWJ, 3G42, 3KMC, 3KME, 3L0T, 3L0V, 3LE9, 3LEA, 3LGP, 3O64
Identifiers
Aliases	ADAM17, ADAM18, CD156B, CSVP, NISBD, NISBD1, TACE, ADAM metallopeptidase domain 17
External IDs	OMIM: 603639; MGI: 1096335; HomoloGene: 2395; GeneCards: ADAM17; OMA:ADAM17 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p25.1 Start 9,488,486 bp[1] End 9,556,732 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 A1.3|12 8.3 cM Start 21,373,510 bp[2] End 21,423,633 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte Achilles tendon pericardium monocyte tendon of biceps brachii sural nerve lower lobe of lung right lung gallbladder upper lobe of lung Top expressed in otic vesicle saccule otic placode primary oocyte secondary oocyte cumulus cell genital tubercle tail of embryo stroma of bone marrow left lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function PDZ domain binding interleukin-6 receptor binding SH3 domain binding metal ion binding Notch binding integrin binding peptidase activity protein binding metalloendopeptidase activity hydrolase activity metallopeptidase activity endopeptidase activity Cellular component cytoplasm integral component of membrane membrane cell-cell junction focal adhesion plasma membrane integral component of plasma membrane ruffle membrane cell surface apical plasma membrane actin cytoskeleton membrane raft cytosol Biological process Notch signaling pathway positive regulation of transforming growth factor beta receptor signaling pathway positive regulation of epidermal growth factor-activated receptor activity positive regulation of protein phosphorylation response to hypoxia T cell differentiation in thymus cell motility positive regulation of cell migration wound healing, spreading of epidermal cells germinal center formation tumor necrosis factor-mediated signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway spleen development proteolysis positive regulation of leukocyte chemotaxis positive regulation of cell growth response to lipopolysaccharide cell adhesion cell adhesion mediated by integrin membrane protein ectodomain proteolysis membrane protein intracellular domain proteolysis regulation of mast cell apoptotic process positive regulation of T cell chemotaxis positive regulation of cell population proliferation Notch receptor processing positive regulation of chemokine production neutrophil mediated immunity B cell differentiation defense response to Gram-positive bacterium epidermal growth factor receptor signaling pathway receptor transactivation positive regulation of blood vessel endothelial cell migration positive regulation of cyclin-dependent protein serine/threonine kinase activity cellular response to high density lipoprotein particle stimulus negative regulation of cold-induced thermogenesis positive regulation of G1/S transition of mitotic cell cycle positive regulation of tumor necrosis factor-mediated signaling pathway positive regulation of vascular endothelial cell proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6868 11491 Ensembl ENSG00000151694 ENSMUSG00000052593 UniProt P78536 Q9Z0F8 RefSeq (mRNA) NM_003183 NM_001382777 NM_001382778 NM_021832 NM_001277266 NM_009615 NM_001291871 RefSeq (protein) NP_003174 NP_001264195 NP_001278800 NP_033745 Location (UCSC) Chr 2: 9.49 – 9.56 Mb Chr 12: 21.37 – 21.42 Mb PubMed search [3] [4]
Wikidata
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A disintegrin and metalloprotease 17 (ADAM17), also called TACE (tumor necrosis factor-α-converting enzyme), is a 70-kDa enzyme that belongs to the ADAM protein family of disintegrins and metalloproteases, activated by substrate presentation.