ADAM22

ADAM22
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3G5C
Identifiers
Aliases	ADAM22, ADAM 22, MDC2, ADAM metallopeptidase domain 22, EIEE61, DEE61
External IDs	OMIM: 603709; MGI: 1340046; HomoloGene: 37898; GeneCards: ADAM22; OMA:ADAM22 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	88,202,889 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	8,418,160 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; middle temporal gyrus; ; pons; ; Brodmann area 23; ; postcentral gyrus; ; orbitofrontal cortex; ; Brodmann area 46; ; cerebellum; ; cerebellar hemisphere; ; superior frontal gyrus;
	Top expressed in
	lobe of cerebellum; ; cerebellar vermis; ; dorsal striatum; ; lateral septal nucleus; ; subiculum; ; anterior amygdaloid area; ; medial geniculate nucleus; ; nucleus accumbens; ; dorsomedial hypothalamic nucleus; ; ventromedial nucleus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	integrin binding; metalloendopeptidase activity; protein binding; metallopeptidase activity;
Cellular component	integral component of membrane; axon; plasma membrane; cell projection; membrane; glutamatergic synapse; integral component of postsynaptic density membrane;
Biological process	Schwann cell differentiation; adult locomotory behavior; negative regulation of cell adhesion; central nervous system development; cell adhesion; myelination in peripheral nervous system; proteolysis; gliogenesis;
	Sources:Amigo / QuickGO
Orthologs
	53616
	11496
	ENSG00000008277
	ENSMUSG00000040537
	Q9P0K1
	Q9R1V6
NM_004194; NM_016351; NM_021721; NM_021722; NM_021723;
	NM_001324417; NM_001324418; NM_001324419; NM_001324420; NM_001324421; NM_001391975; NM_001391976; NM_001391977; NM_001391978; NM_001391979; NM_001391980; NM_001391981; NM_001391982
	NM_001007220; NM_001007221; NM_001098225; NM_001310439; NM_001310440
NP_001311346; NP_001311347; NP_001311348; NP_001311349; NP_001311350;
	NP_004185; NP_057435; NP_068367; NP_068368; NP_068369
	NP_001007221; NP_001007222; NP_001091695; NP_001297368; NP_001297369
	Wikidata
View/Edit Human	View/Edit Mouse

Disintegrin and metalloproteinase domain-containing protein 22, also known as ADAM22, is an enzyme that in humans is encoded by the ADAM22 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000008277 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040537 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sagane K, Ohya Y, Hasegawa Y, Tanaka I (August 1998). "Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain". The Biochemical Journal. 334 ( Pt 1) (Pt 1): 93–8. doi:10.1042/bj3340093. PMC 1219666. PMID 9693107.
^ Poindexter K, Nelson N, DuBose RF, Black RA, Cerretti DP (September 1999). "The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries". Gene. 237 (1): 61–70. doi:10.1016/S0378-1119(99)00302-9. PMID 10524237.
^ "Entrez Gene: ADAM22 ADAM metallopeptidase domain 22".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000008277 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040537 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9693107-5] Sagane K, Ohya Y, Hasegawa Y, Tanaka I (August 1998). "Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain". The Biochemical Journal. 334 ( Pt 1) (Pt 1): 93–8. doi:10.1042/bj3340093. PMC 1219666. PMID 9693107.

[pmid10524237-6] Poindexter K, Nelson N, DuBose RF, Black RA, Cerretti DP (September 1999). "The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries". Gene. 237 (1): 61–70. doi:10.1016/S0378-1119(99)00302-9. PMID 10524237.

[entrez-7] "Entrez Gene: ADAM22 ADAM metallopeptidase domain 22".

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