ADAM9

ADAM9
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1M1V
Identifiers
Aliases	ADAM9, CORD9, MCMP, MDC9, Mltng, ADAM metallopeptidase domain 9
External IDs	OMIM: 602713; MGI: 105376; HomoloGene: 20824; GeneCards: ADAM9; OMA:ADAM9 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	39,105,445 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	25,506,943 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; islet of Langerhans; ; gallbladder; ; smooth muscle tissue; ; right lung; ; Descending thoracic aorta; ; Achilles tendon; ; ascending aorta; ; upper lobe of left lung; ; rectum;
	Top expressed in
	endothelial cell of lymphatic vessel; ; stroma of bone marrow; ; seminal vesicula; ; retinal pigment epithelium; ; epithelium of lens; ; left lung lobe; ; Paneth cell; ; right lung; ; parotid gland; ; gastric mucosa;
	More reference expression data
	n/a
Gene ontology
Molecular function	collagen binding; SH3 domain binding; metal ion binding; integrin binding; peptidase activity; protein binding; metalloendopeptidase activity; laminin binding; hydrolase activity; metallopeptidase activity; protein kinase C binding;
Cellular component	integral component of membrane; membrane; focal adhesion; intrinsic component of external side of plasma membrane; plasma membrane; extracellular region; extracellular exosome; cell surface; basolateral plasma membrane; extracellular space;
Biological process	positive regulation of membrane protein ectodomain proteolysis; response to glucocorticoid; positive regulation of macrophage fusion; cell-cell adhesion mediated by integrin; keratinocyte differentiation; proteolysis; monocyte activation; response to calcium ion; response to tumor necrosis factor; positive regulation of keratinocyte migration; cell adhesion; response to manganese ion; membrane protein ectodomain proteolysis; positive regulation of protein secretion; integrin-mediated signaling pathway; positive regulation of cell adhesion mediated by integrin; cell-matrix adhesion; cellular response to lipopolysaccharide; transforming growth factor beta receptor signaling pathway; response to hydrogen peroxide; cell migration; cell adhesion mediated by integrin; response to laminar fluid shear stress; response to antineoplastic agent;
	Sources:Amigo / QuickGO
Orthologs
	8754
	11502
	ENSG00000168615; ENSG00000282230
	ENSMUSG00000031555
	Q13443
	Q61072
	NM_001005845; NM_003816
	NM_001270996; NM_007404
	NP_003807
	NP_001257925; NP_031430
	Wikidata
View/Edit Human	View/Edit Mouse

Disintegrin and metalloproteinase domain-containing protein 9 is an enzyme that in humans is encoded by the ADAM9 gene.^[5]^[6]

^ ^a ^b ^c ENSG00000282230 GRCh38: Ensembl release 89: ENSG00000168615, ENSG00000282230 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031555 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Weskamp G, Kratzschmar J, Reid MS, Blobel CP (Jul 1996). "MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains". J Cell Biol. 132 (4): 717–26. doi:10.1083/jcb.132.4.717. PMC 2199860. PMID 8647900.
^ "Entrez Gene: ADAM9 ADAM metallopeptidase domain 9 (meltrin gamma)".

[refGRCh38Ensembl-1] ENSG00000282230 GRCh38: Ensembl release 89: ENSG00000168615, ENSG00000282230 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031555 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8647900-5] Weskamp G, Kratzschmar J, Reid MS, Blobel CP (Jul 1996). "MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains". J Cell Biol. 132 (4): 717–26. doi:10.1083/jcb.132.4.717. PMC 2199860. PMID 8647900.

[entrez-6] "Entrez Gene: ADAM9 ADAM metallopeptidase domain 9 (meltrin gamma)".

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