ADAMTS3

ADAMTS3
Identifiers
Aliases	ADAMTS3, ADAMTS-4, ADAM metallopeptidase with thrombospondin type 1 motif 3, HKLLS3
External IDs	OMIM: 605011; MGI: 3045353; HomoloGene: 8596; GeneCards: ADAMTS3; OMA:ADAMTS3 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	72,569,221 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	90,031,193 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; cartilage tissue; ; periodontal fiber; ; parietal pleura; ; germinal epithelium; ; tibia; ; testicle; ; caput epididymis; ; secondary oocyte; ; left uterine tube;
	Top expressed in
	neural layer of retina; ; superior frontal gyrus; ; zygote; ; genital tubercle; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; ventricular zone; ; embryo; ; tail of embryo; ; secondary oocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	heparin binding; zinc ion binding; endopeptidase activity; metal ion binding; peptidase activity; protein binding; hydrolase activity; metallopeptidase activity; metalloendopeptidase activity;
Cellular component	extracellular region; extracellular exosome; extracellular space; extracellular matrix; collagen-containing extracellular matrix;
Biological process	vascular endothelial growth factor production; collagen fibril organization; protein processing; proteolysis; collagen biosynthetic process; positive regulation of vascular endothelial growth factor signaling pathway; collagen catabolic process; supramolecular fiber organization;
	Sources:Amigo / QuickGO
Orthologs
	9508
	330119
	ENSG00000156140
	ENSMUSG00000043635
	O15072
	n/a
	NM_014243
	NM_001081401; NM_177872
	NP_055058
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

A disintegrin and metalloproteinase with thrombospondin motifs 3 is an enzyme that in humans is encoded by the ADAMTS3 gene.^[5]^[6] The protein encoded by this gene is the major procollagen II N-propeptidase.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000156140 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000043635 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tang BL, Hong W (February 1999). "ADAMTS: a novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats". FEBS Letters. 445 (2–3): 223–5. doi:10.1016/S0014-5793(99)00119-2. PMID 10094461. S2CID 37955930.
^ ^a ^b "Entrez Gene: ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000156140 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000043635 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10094461-5] Tang BL, Hong W (February 1999). "ADAMTS: a novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats". FEBS Letters. 445 (2–3): 223–5. doi:10.1016/S0014-5793(99)00119-2. PMID 10094461. S2CID 37955930.

[entrez-6] "Entrez Gene: ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3".

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