ADCY2

ADCY2
Identifiers
Aliases	ADCY2, AC2, HBAC2, adenylate cyclase 2 (brain), adenylate cyclase 2
External IDs	OMIM: 103071; MGI: 99676; HomoloGene: 75133; GeneCards: ADCY2; OMA:ADCY2 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5p15.31 Start 7,396,138 bp[1] End 7,830,081 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 B3|13 35.55 cM Start 68,768,162 bp[2] End 69,147,660 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus Brodmann area 23 dorsal motor nucleus of vagus nerve Skeletal muscle tissue of rectus abdominis entorhinal cortex postcentral gyrus muscle of thigh biceps brachii deltoid muscle Skeletal muscle tissue of biceps brachii Top expressed in primary motor cortex CA3 field cingulate gyrus digastric muscle Region I of hippocampus proper primary visual cortex temporal muscle superior frontal gyrus extraocular muscle sternocleidomastoid muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding manganese ion binding adenylate cyclase binding metal ion binding lyase activity protein heterodimerization activity phosphorus-oxygen lyase activity ATP binding magnesium ion binding guanylate cyclase activity adenylate cyclase activity Cellular component cytoplasm integral component of membrane membrane plasma membrane integral component of plasma membrane intracellular anatomical structure dendrite membrane raft guanylate cyclase complex, soluble Biological process intracellular signal transduction cellular response to forskolin adenylate cyclase-modulating G protein-coupled receptor signaling pathway cellular response to glucagon stimulus cyclic nucleotide biosynthetic process renal water homeostasis cAMP biosynthetic process cGMP biosynthetic process signal transduction adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway cAMP-mediated signaling G protein-coupled receptor signaling pathway activation of adenylate cyclase activity activation of protein kinase A activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 108 210044 Ensembl ENSG00000078295 ENSMUSG00000021536 UniProt Q08462 Q80TL1 Q3V1Q3 RefSeq (mRNA) NM_020546 NM_153534 RefSeq (protein) NP_065433 NP_705762 Location (UCSC) Chr 5: 7.4 – 7.83 Mb Chr 13: 68.77 – 69.15 Mb PubMed search [3] [4]
Wikidata
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Adenylyl cyclase type 2 is an enzyme typically expressed in the brain of humans, that is encoded by the ADCY2 gene.^[5][6] It belongs to the adenylyl cyclase class-3 or guanylyl cyclase family because it contains two guanylate cyclase domains.^[7] ADCY2 is one of ten different mammalian isoforms of adenylyl cyclases. ADCY2 can be found on chromosome 5 and the "MIR2113-POU3F2" region of chromosome 6, with a length of 1091 amino-acids. An essential cofactor for ADCY2 is magnesium; two ions bind per subunit.^[7]