ADCY8

ADCY8
Identifiers
Aliases	ADCY8, AC8, ADCY3, HBAC1, adenylate cyclase 8 (brain), adenylate cyclase 8
External IDs	OMIM: 103070; MGI: 1341110; HomoloGene: 37443; GeneCards: ADCY8; OMA:ADCY8 - orthologs
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	64,794,145 bp
RNA expression pattern
	Top expressed in
	caput epididymis; ; inferior olivary nucleus; ; corpus epididymis; ; external globus pallidus; ; pons; ; amygdala; ; prefrontal cortex; ; cingulate gyrus; ; hypothalamus; ; substantia nigra;
	Top expressed in
	ventral lateral nucleus; ; central medial nucleus; ; medial dorsal nucleus; ; medial geniculate nucleus; ; supraoptic nucleus; ; lateral geniculate nucleus; ; lumbar subsegment of spinal cord; ; ganglion cell layer; ; layer of neocortex; ; efferent ductule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; metal ion binding; lyase activity; adenylate cyclase activity; phosphorus-oxygen lyase activity; calcium- and calmodulin-responsive adenylate cyclase activity; ATP binding; guanylate cyclase activity; actin binding; calmodulin binding; protein homodimerization activity; protein heterodimerization activity; protein dimerization activity; protein phosphatase 2A binding;
Cellular component	integral component of membrane; membrane; plasma membrane; guanylate cyclase complex, soluble; Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; glutamatergic synapse; integral component of presynaptic membrane; intracellular anatomical structure; integral component of plasma membrane; caveola; clathrin-coated pit; postsynaptic density; actin cytoskeleton; basolateral plasma membrane; apical plasma membrane; axon; dendrite; neuronal cell body membrane; plasma membrane raft; membrane raft; presynaptic active zone; excitatory synapse; cell junction; clathrin-coated vesicle membrane; cytoplasmic vesicle; presynaptic membrane; cell projection; synapse; postsynaptic membrane;
Biological process	cAMP biosynthetic process; intracellular signal transduction; cellular response to glucagon stimulus; cyclic nucleotide biosynthetic process; long-term memory; renal water homeostasis; learning or memory; signal transduction; cGMP biosynthetic process; adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway; modulation of chemical synaptic transmission; positive regulation of cytosolic calcium ion concentration; memory; locomotory behavior; glucose mediated signaling pathway; positive regulation of synaptic plasticity; positive regulation of CREB transcription factor activity; activation of protein kinase A activity; positive regulation of insulin secretion involved in cellular response to glucose stimulus; G protein-coupled opioid receptor signaling pathway; glucose homeostasis; protein complex oligomerization; protein homooligomerization; regulation of cytosolic calcium ion concentration; cellular response to calcium ion; cellular response to morphine; cellular response to glucose stimulus; regulation of cellular response to stress; neuroinflammatory response; positive regulation of long-term synaptic potentiation; positive regulation of long-term synaptic depression; cellular response to forskolin; activation of adenylate cyclase activity;
	Sources:Amigo / QuickGO
Orthologs
	114
	11514
	n/a
	ENSMUSG00000022376
	P40145; Q4F7X0
	P97490
	NM_001115
	NM_001291903; NM_009623; NM_001331075
	NP_001106; NP_001106.1
	NP_001278832; NP_001318004; NP_033753
	Wikidata
View/Edit Human	View/Edit Mouse

Adenylyl cyclase type 8 is an enzyme that in humans is encoded by the ADCY8 gene.^[4]^[5]

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022376 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Defer N, Marinx O, Stengel D, Danisova A, Iourgenko V, Matsuoka I, Caput D, Hanoune J (Aug 1994). "Molecular cloning of the human type VIII adenylyl cyclase". FEBS Letters. 351 (1): 109–13. doi:10.1016/0014-5793(94)00836-1. PMID 8076676. S2CID 7559521.
^ "Entrez Gene: ADCY8 adenylate cyclase 8 (brain)".

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000022376 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8076676-4] Defer N, Marinx O, Stengel D, Danisova A, Iourgenko V, Matsuoka I, Caput D, Hanoune J (Aug 1994). "Molecular cloning of the human type VIII adenylyl cyclase". FEBS Letters. 351 (1): 109–13. doi:10.1016/0014-5793(94)00836-1. PMID 8076676. S2CID 7559521.

[entrez-5] "Entrez Gene: ADCY8 adenylate cyclase 8 (brain)".

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