ADH1B

ADH1B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1DEH, 1HDX, 1HDY, 1HDZ, 1HSZ, 1HTB, 1U3U, 1U3V, 3HUD
Identifiers
Aliases	ADH1B, ADH2, HEL-S-117, alcohol dehydrogenase 1B (class I), beta polypeptide
External IDs	OMIM: 103720; MGI: 87921; HomoloGene: 133563; GeneCards: ADH1B; OMA:ADH1B - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	99,352,760 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	137,996,459 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; right coronary artery; ; lower lobe of lung; ; abdominal fat; ; gastric mucosa; ; Descending thoracic aorta; ; left coronary artery; ; right lung; ; superficial temporal artery; ; left uterine tube;
	Top expressed in
	conjunctival fornix; ; left lung lobe; ; transitional epithelium of urinary bladder; ; left colon; ; adrenal gland; ; left lobe of liver; ; gallbladder; ; seminal vesicula; ; efferent ductule; ; right kidney;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity; zinc ion binding; alcohol dehydrogenase (NAD+) activity; metal ion binding; alcohol dehydrogenase activity, zinc-dependent; NAD-retinol dehydrogenase activity;
Cellular component	cytoplasm; nucleoplasm; cytosol; plasma membrane;
Biological process	ethanol oxidation; retinol metabolic process; retinoic acid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	125
	11522
	ENSG00000196616
	ENSMUSG00000074207
	P00325
	P00329
	NM_001286650; NM_000668
	NM_007409
	NP_000659; NP_001273579
	NP_031435
	Wikidata
View/Edit Human	View/Edit Mouse

Alcohol dehydrogenase 1B is an enzyme that in humans is encoded by the ADH1B gene.^[5]^[6]

The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol (beverage alcohol), retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein, known as ADH1B or beta-ADH, can form homodimers and heterodimers with ADH1A and ADH1C subunits, exhibits high activity for ethanol oxidation^[7]^[8] and plays a major role in ethanol catabolism (oxidizing ethanol into acetaldehyde). The acetaldehyde is further metabolized to acetate by aldehyde dehydrogenase genes. Three genes encoding the closely related alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster.^[9]

The human gene is located on chromosome 4 in 4q22.

Previously ADH1B was called ADH2. There are more genes in the family of alcohol dehydrogenase. These genes are now referred to as ADH1A, ADH1C, and ADH4, ADH5, ADH6 and ADH7.^[10]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000196616 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000074207 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Smith M (Mar 1986). "Genetics of Human Alcohol and Aldehyde Dehydrogenases". Advances in Human Genetics 15. Vol. 15. pp. 249–90. doi:10.1007/978-1-4615-8356-1_5. ISBN 978-1-4615-8358-5. PMID 3006456.
^ Hurley TD, Edenberg HJ (2012). "Genes encoding enzymes involved in ethanol metabolism". Alcohol Research. 34 (3): 339–44. PMC 3756590. PMID 23134050.
^ Hurley TD, Edenberg HJ, Bosron WF (1990). "Expression and kinetic characterization of variants of human beta 1 beta 1 alcohol dehydrogenase containing substitutions at amino acid 47". J. Biol. Chem. 265 (27): 16366–72. doi:10.1016/S0021-9258(17)46232-6. PMID 2398055.
^ Hurley TD, Edenberg HJ (2012). "Genes encoding enzymes involved in ethanol metabolism". Alcohol Research. 34 (3): 339–44. PMC 3756590. PMID 23134050.
^ "Entrez Gene: ADH1B alcohol dehydrogenase IB (class I), beta polypeptide". Retrieved 2019-12-19.
^ Hurley TD, Edenberg HJ (2012). "Genes encoding enzymes involved in ethanol metabolism". Alcohol Research. 34 (3): 339–44. PMC 3756590. PMID 23134050.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000196616 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000074207 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3006456-5] Smith M (Mar 1986). "Genetics of Human Alcohol and Aldehyde Dehydrogenases". Advances in Human Genetics 15. Vol. 15. pp. 249–90. doi:10.1007/978-1-4615-8356-1_5. ISBN 978-1-4615-8358-5. PMID 3006456.

[6] Hurley TD, Edenberg HJ (2012). "Genes encoding enzymes involved in ethanol metabolism". Alcohol Research. 34 (3): 339–44. PMC 3756590. PMID 23134050.

[7] Hurley TD, Edenberg HJ, Bosron WF (1990). "Expression and kinetic characterization of variants of human beta 1 beta 1 alcohol dehydrogenase containing substitutions at amino acid 47". J. Biol. Chem. 265 (27): 16366–72. doi:10.1016/S0021-9258(17)46232-6. PMID 2398055.

[8] Hurley TD, Edenberg HJ (2012). "Genes encoding enzymes involved in ethanol metabolism". Alcohol Research. 34 (3): 339–44. PMC 3756590. PMID 23134050.

[entrez-9] "Entrez Gene: ADH1B alcohol dehydrogenase IB (class I), beta polypeptide". Retrieved 2019-12-19.

[10] Hurley TD, Edenberg HJ (2012). "Genes encoding enzymes involved in ethanol metabolism". Alcohol Research. 34 (3): 339–44. PMC 3756590. PMID 23134050.

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