ADH5

ADH5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesADH5, ADH-3, ADHX, FALDH, FDH, GSH-FDH, GSNOR, HEL-S-60p, alcohol dehydrogenase 5 (class III), chi polypeptide, BMFS7, AMEDS
External IDsOMIM: 103710; MGI: 87929; HomoloGene: 68076; GeneCards: ADH5; OMA:ADH5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000671

NM_001288578
NM_007410

RefSeq (protein)

NP_000662

NP_001275507
NP_031436

Location (UCSC)Chr 4: 99.07 – 99.09 MbChr 3: 138.15 – 138.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Alcohol dehydrogenase class-3 is an enzyme that in humans is encoded by the ADH5 gene.[5][6][7]

This gene encodes glutathione-dependent formaldehyde dehydrogenase or the class III alcohol dehydrogenase chi subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class III alcohol dehydrogenase is a homodimer composed of 2 chi subunits. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione.

This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis.[7]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000197894Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028138Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hur MW, Edenberg HJ (Dec 1992). "Cloning and characterization of the ADH5 gene encoding human alcohol dehydrogenase 5, formaldehyde dehydrogenase". Gene. 121 (2): 305–11. doi:10.1016/0378-1119(92)90135-C. PMID 1446828.
  6. ^ Adinolfi A, Adinolfi M, Hopkinson DA (May 1984). "Immunological and biochemical characterization of the human alcohol dehydrogenase chi-ADH isozyme". Ann Hum Genet. 48 (Pt 1): 1–10. doi:10.1111/j.1469-1809.1984.tb00828.x. PMID 6424546. S2CID 85113864.
  7. ^ a b "Entrez Gene: ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide".