ADP/ATP translocase 2 is a protein that in humans is encoded by the SLC25A5 gene on the X chromosome.[5]
This protein functions as an antiporter for ADP/ATP exchange between the mitochondrial matrix and cytoplasm.[5][6][7] As a result, it plays a key role in maintaining mitochondrial membrane potential and inhibiting apoptosis and has been targeted for treating cancer.[5][6]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000005022 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000016319 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b c "Entrez Gene: Solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5". Retrieved 2013-09-18.
- ^ a b Chevrollier A, Loiseau D, Reynier P, Stepien G (Jun 2011). "Adenine nucleotide translocase 2 is a key mitochondrial protein in cancer metabolism". Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1807 (6): 562–7. doi:10.1016/j.bbabio.2010.10.008. PMID 20950584.
- ^ Ho L, Titus AS, Banerjee KK, George S, Lin W, Deota S, Saha AK, Nakamura K, Gut P, Verdin E, Kolthur-Seetharam U (Nov 2013). "SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK". Aging. 5 (11): 835–49. doi:10.18632/aging.100616. PMC 3868726. PMID 24296486.