AEBSF

AEBSF
Names
	Preferred IUPAC name 4-(2-Aminoethyl)benzene-1-sulfonyl fluoride
	Other names Pefabloc SC
Identifiers
CAS Number	34284-75-8 ; 30827-99-7 (hydrochloride salt);
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL1096339 ;
ChemSpider	1638 ;
DrugBank	DB07347 ;
MeSH	AEBSF
PubChem CID	1701;
UNII	F5D36L5354 ;
CompTox Dashboard (EPA)	DTXSID40187844 ;
	InChI InChI=1S/C8H10FNO2S/c9-13(11,12)8-3-1-7(2-4-8)5-6-10/h1-4H,5-6,10H2 Key: MGSKVZWGBWPBTF-UHFFFAOYSA-N ; InChI=1/C8H10FNO2S/c9-13(11,12)8-3-1-7(2-4-8)5-6-10/h1-4H,5-6,10H2 Key: MGSKVZWGBWPBTF-UHFFFAOYAK;
	SMILES FS(=O)(=O)c1ccc(cc1)CCN;
Properties
Chemical formula	C8H10FNO2S.HCl
Molar mass	239.69 g/mol
Solubility in water	200 mg/mL
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

AEBSF or 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride is a water-soluble, irreversible serine protease inhibitor with a molecular weight of 239.5 Da. It inhibits proteases like chymotrypsin, kallikrein, plasmin, thrombin, and trypsin. The specificity is similar to the inhibitor PMSF, nevertheless AEBSF is more stable at low pH values. Typical usage is 0.1 - 1.0 mM. AEBSF (marketed as Pefabloc SC from the company Pentapharm) was first reported for use in biochemistry in 1993, and came into common use for the inhibition serine proteases and of non-protease enzymes such as acetylhydrolases in the mid 1990s.^[2]

^ "Pefabloc® SC" (PDF). Pentapharm. Retrieved 22 June 2023.
^ Dentan C, Tselepis AD, Chapman M, Ninio E (1996). "Pefabloc, 4-[2-aminoethyl]benzenesulfonyl fluoride, is a new, potent nontoxic and irreversible inhibitor of PAF-degrading acetylhydrolase". Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1299 (3). Elsevier BV: 353–357. doi:10.1016/0005-2760(95)00226-x. ISSN 0005-2760. PMID 8597590.

[1] "Pefabloc® SC" (PDF). Pentapharm. Retrieved 22 June 2023.

[Dentan1996-2] Dentan C, Tselepis AD, Chapman M, Ninio E (1996). "Pefabloc, 4-[2-aminoethyl]benzenesulfonyl fluoride, is a new, potent nontoxic and irreversible inhibitor of PAF-degrading acetylhydrolase". Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1299 (3). Elsevier BV: 353–357. doi:10.1016/0005-2760(95)00226-x. ISSN 0005-2760. PMID 8597590.

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