AGPAT3

AGPAT3
Identifiers
Aliases	AGPAT3, LPAAT-GAMMA1, LPAAT3, 1-acylglycerol-3-phosphate O-acyltransferase 3, 1-AGPAT 3
External IDs	OMIM: 614794; MGI: 1336186; HomoloGene: 10591; GeneCards: AGPAT3; OMA:AGPAT3 - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	43,987,592 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	78,188,323 bp
RNA expression pattern
	Top expressed in
	external globus pallidus; ; Brodmann area 23; ; middle temporal gyrus; ; entorhinal cortex; ; postcentral gyrus; ; primary visual cortex; ; parotid gland; ; jejunal mucosa; ; subthalamic nucleus; ; endothelial cell;
	Top expressed in
	neural layer of retina; ; saccule; ; seminiferous tubule; ; otic placode; ; right kidney; ; spermatid; ; brown adipose tissue; ; otic vesicle; ; lip; ; proximal tubule;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; acyltransferase activity; lysophosphatidic acid acyltransferase activity; 1-acylglycerol-3-phosphate O-acyltransferase activity;
Cellular component	integral component of membrane; plasma membrane; nuclear envelope; endoplasmic reticulum; endoplasmic reticulum membrane; membrane; nucleus; Golgi membrane;
Biological process	phosphatidic acid biosynthetic process; CDP-diacylglycerol biosynthetic process; metabolism; phospholipid biosynthetic process; lipid metabolism; phospholipid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	56894
	28169
	ENSG00000160216
	ENSMUSG00000001211
	Q9NRZ7
	Q9D517
	NM_001037553; NM_020132; NM_001369878; NM_001369880; NM_001369881
	NM_053014
	NP_001032642; NP_064517; NP_001356807; NP_001356809; NP_001356810
NP_443747; NP_001391799; NP_001391800; NP_001391801; NP_001391802;
	NP_001391803; NP_001391804; NP_001391805; NP_001391806; NP_001391807; NP_001391808; NP_001391809; NP_001391810; NP_001391811
	Wikidata
View/Edit Human	View/Edit Mouse

1-acyl-sn-glycerol-3-phosphate acyltransferase gamma is an enzyme that in humans is encoded by the AGPAT3 gene.^[5]

The protein encoded by this gene is an acyltransferase (specifically, 1-acylglycerol-3-phosphate O-acyltransferase) that converts lysophosphatidic acid (1-acyl-sn-glycerol 3-phosphate) into phosphatidic acid, which is the second step in the de novo phospholipid biosynthetic pathway. The encoded protein may be an integral membrane protein. Two transcript variants encoding the same protein have been found for this gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000160216 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000001211 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000160216 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000001211 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3".

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