AH-1058

AH-1058
Legal status
Legal status
  • Investigational
Identifiers
  • 1-[(E)-3-(3-Methoxy-2-nitrophenyl)prop-2-enyl]-4-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenylidene)piperidine
CAS Number
PubChem CID
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC30H28N2O3
Molar mass464.565 g·mol−1
3D model (JSmol)
  • COC1=CC=CC(=C1[N+](=O)[O-])/C=C/CN2CCC(=C3C4=CC=CC=C4C=CC5=CC=CC=C53)CC2

AH-1058 is a lipophilic antiarrhythmic calcium channel blocker synthesized by the Pharmaceutical Research Laboratories of Ajinomoto Co., Inc in Kawasaki, Japan.[1] It is derived from cyproheptadine, a compound with known antiserotonic, antihistaminic and calcium channel blocking properties.[1][2] The IUPAC name of AH-1058 is: 4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-[E-3-(3-methoxy-2-nitro) phenyl-2-propenyl]piperidine hydrochloride.[3]

  1. ^ a b Takahara A, Uneyama H, Sasaki N, Ueda H, Dohmoto H, Shoji M, Hara Y, Nakaya H, Yoshimoto R (April 1999). "Effects of AH-1058, a new antiarrhythmic drug, on experimental arrhythmias and cardiac membrane currents". Journal of Cardiovascular Pharmacology. 33 (4): 625–32. doi:10.1097/00005344-199904000-00016. PMID 10218734.
  2. ^ Kotake H, Saitoh M, Ogino K, Hirai S, Matsuoka S, Hasegawa J, Mashiba H (July 1987). "On the ionic mechanism of cyproheptadine-induced bradycardia in a rabbit sinoatrial node preparation". European Journal of Pharmacology. 139 (3): 307–13. doi:10.1016/0014-2999(87)90588-7. PMID 3666007.
  3. ^ Takahara A, Sugiyama A, Dohmoto H, Yoshimoto R, Hashimoto K (June 2000). "Electrophysiological and cardiohemodynamic effects of AH-1058, a new type calcium channel blocker, assessed by the in vivo canine model". Japanese Journal of Pharmacology. 83 (2): 107–12. doi:10.1254/jjp.83.107. PMID 10928322.