AKAP9

AKAP9
Identifiers
Aliases	AKAP9, AKAP-9, AKAP350, AKAP450, CG-NAP, HYPERION, LQT11, MU-RMS-40.16A, PPP1R45, PRKA9, YOTIAO, A-kinase anchoring protein 9
External IDs	OMIM: 604001; HomoloGene: 17517; GeneCards: AKAP9; OMA:AKAP9 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	92,110,673 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; bronchial epithelial cell; ; sural nerve; ; Achilles tendon; ; Skeletal muscle tissue of rectus abdominis; ; epithelium of colon; ; gastric mucosa; ; right uterine tube; ; Skeletal muscle tissue of biceps brachii; ; mucosa of paranasal sinus;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transmembrane transporter binding; potassium channel regulator activity; protein binding; molecular adaptor activity; signaling receptor binding; protein kinase A regulatory subunit binding; DNA binding; kinase activity;
Cellular component	cytoplasm; cytosol; centrosome; Golgi apparatus; intracellular membrane-bounded organelle; voltage-gated potassium channel complex; cis-Golgi network; microtubule organizing center; Golgi stack; cytoskeleton; dendritic branch; synaptic membrane; soma; glutamatergic synapse; extrinsic component of postsynaptic density membrane;
Biological process	positive regulation of peptidyl-serine phosphorylation; MAPK cascade; G2/M transition of mitotic cell cycle; regulation of membrane repolarization; regulation of heart rate by cardiac conduction; cellular response to cAMP; signal transduction; positive regulation of potassium ion transmembrane transporter activity; microtubule nucleation; regulation of ventricular cardiac muscle cell membrane repolarization; chemical synaptic transmission; response to electrical stimulus; negative regulation of adenylate cyclase activity; ciliary basal body-plasma membrane docking; regulation of cardiac muscle cell action potential involved in regulation of contraction; maintenance of centrosome location; regulation of G2/M transition of mitotic cell cycle; regulation of Golgi organization; positive regulation of microtubule polymerization; regulation of postsynaptic neurotransmitter receptor activity; cardiac conduction; phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	10142
	n/a
	ENSG00000127914
	n/a
	Q99996; Q6PJH3
	n/a
	NM_005751; NM_147166; NM_147171; NM_147185; NM_001379277
	n/a
	NP_005742; NP_671714; NP_001366206; NP_005742.4; NP_671714.1
	n/a
	Wikidata
View/Edit Human

A-kinase anchor protein 9 is a protein that in humans is encoded by the AKAP9 gene.^[3]^[4]^[5] AKAP9 is also known as Centrosome- and Golgi-localized protein kinase N-associated protein (CG-NAP) or AKAP350 or AKAP450 ^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000127914 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lin JW, Wyszynski M, Madhavan R, Sealock R, Kim JU, Sheng M (Apr 1998). "Yotiao, a novel protein of neuromuscular junction and brain that interacts with specific splice variants of NMDA receptor subunit NR1". J Neurosci. 18 (6): 2017–27. doi:10.1523/JNEUROSCI.18-06-02017.1998. PMC 6792910. PMID 9482789.
^ Westphal RS, Tavalin SJ, Lin JW, Alto NM, Fraser ID, Langeberg LK, Sheng M, Scott JD (Jul 1999). "Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex". Science. 285 (5424): 93–6. doi:10.1126/science.285.5424.93. PMID 10390370.
^ "Entrez Gene: AKAP9 A kinase (PRKA) anchor protein (yotiao) 9".
^ Ong ST, Chalasani ML, Fazil MH, Prasannan P, Kizhakeyil A, Wright GD, Kelleher D, Verma NK (Mar 2018). "Centrosome- and Golgi-Localized Protein Kinase N-Associated Protein Serves As a Docking Platform for Protein Kinase A Signaling and Microtubule Nucleation in Migrating T-Cells". Front. Immunol. 9 (397): 397. doi:10.3389/fimmu.2018.00397. PMC 5837996. PMID 29545805.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000127914 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9482789-3] Lin JW, Wyszynski M, Madhavan R, Sealock R, Kim JU, Sheng M (Apr 1998). "Yotiao, a novel protein of neuromuscular junction and brain that interacts with specific splice variants of NMDA receptor subunit NR1". J Neurosci. 18 (6): 2017–27. doi:10.1523/JNEUROSCI.18-06-02017.1998. PMC 6792910. PMID 9482789.

[pmid10390370-4] Westphal RS, Tavalin SJ, Lin JW, Alto NM, Fraser ID, Langeberg LK, Sheng M, Scott JD (Jul 1999). "Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex". Science. 285 (5424): 93–6. doi:10.1126/science.285.5424.93. PMID 10390370.

[entrez-5] "Entrez Gene: AKAP9 A kinase (PRKA) anchor protein (yotiao) 9".

[gcnap-6] Ong ST, Chalasani ML, Fazil MH, Prasannan P, Kizhakeyil A, Wright GD, Kelleher D, Verma NK (Mar 2018). "Centrosome- and Golgi-Localized Protein Kinase N-Associated Protein Serves As a Docking Platform for Protein Kinase A Signaling and Microtubule Nucleation in Migrating T-Cells". Front. Immunol. 9 (397): 397. doi:10.3389/fimmu.2018.00397. PMC 5837996. PMID 29545805.

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