AKR7A2

AKR7A2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2BP1
Identifiers
Aliases	AKR7A2, AFAR, AFAR1, AFB1-AR1, AKR7, aldo-keto reductase family 7, member A2, aldo-keto reductase family 7 member A2
External IDs	OMIM: 603418; MGI: 107796; HomoloGene: 2737; GeneCards: AKR7A2; OMA:AKR7A2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	19,312,144 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	139,045,737 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; duodenum; ; right adrenal gland; ; right adrenal cortex; ; right uterine tube; ; left adrenal gland; ; jejunal mucosa; ; left adrenal cortex; ; human kidney; ; canal of the cervix;
	Top expressed in
	right kidney; ; proximal tubule; ; left lobe of liver; ; Paneth cell; ; human kidney; ; internal carotid artery; ; crypt of lieberkuhn of small intestine; ; external carotid artery; ; right ventricle; ; motor neuron;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	alditol:NADP+ 1-oxidoreductase activity; electron transfer activity; oxidoreductase activity; phenanthrene-9,10-epoxide hydrolase activity; aldo-keto reductase (NADP) activity; protein binding;
Cellular component	cytoplasm; Golgi apparatus; extracellular exosome; cytosol;
Biological process	xenobiotic metabolic process; cellular aldehyde metabolic process; daunorubicin metabolic process; doxorubicin metabolic process; carbohydrate metabolic process; electron transport chain;
	Sources:Amigo / QuickGO
Orthologs
	8574
	110198
	ENSG00000053371
	ENSMUSG00000028743
	O43488
	Q8CG76
	NM_003689; NM_001320979
	NM_025337
	NP_001307908; NP_003680
	NP_079613
	Wikidata
View/Edit Human	View/Edit Mouse

Aflatoxin B1 aldehyde reductase member 2 is an enzyme that in humans is encoded by the AKR7A2 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000053371 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028743 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ireland LS, Harrison DJ, Neal GE, Hayes JD (Aug 1998). "Molecular cloning, expression and catalytic activity of a human AKR7 member of the aldo-keto reductase superfamily: evidence that the major 2-carboxybenzaldehyde reductase from human liver is a homologue of rat aflatoxin B1-aldehyde reductase". Biochem J. 332 (1): 21–34. doi:10.1042/bj3320021. PMC 1219447. PMID 9576847.
^ "Entrez Gene: AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000053371 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028743 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9576847-5] Ireland LS, Harrison DJ, Neal GE, Hayes JD (Aug 1998). "Molecular cloning, expression and catalytic activity of a human AKR7 member of the aldo-keto reductase superfamily: evidence that the major 2-carboxybenzaldehyde reductase from human liver is a homologue of rat aflatoxin B1-aldehyde reductase". Biochem J. 332 (1): 21–34. doi:10.1042/bj3320021. PMC 1219447. PMID 9576847.

[entrez-6] "Entrez Gene: AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)".

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