AKT1S1

AKT1S1
Identifiers
Aliases	AKT1S1, Lobe, PRAS40, AKT1 substrate 1
External IDs	OMIM: 610221; MGI: 1914855; HomoloGene: 12162; GeneCards: AKT1S1; OMA:AKT1S1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	49,878,459 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	44,504,845 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; muscle of thigh; ; right adrenal gland; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; mucosa of transverse colon; ; skin of leg; ; apex of heart; ; gastric mucosa;
	Top expressed in
	muscle of thigh; ; yolk sac; ; extensor digitorum longus muscle; ; knee joint; ; molar; ; lip; ; vastus lateralis muscle; ; atrium; ; esophagus; ; plantaris muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	TORC1 complex; nucleus; nucleoplasm; cytoplasm; cytosol; protein-containing complex;
Biological process	regulation of cellular response to heat; negative regulation of TOR signaling; regulation of neuron apoptotic process; negative regulation of protein kinase activity; negative regulation of cell size; neurotrophin TRK receptor signaling pathway; TORC1 signaling; regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	84335
	67605
	ENSG00000204673
	ENSMUSG00000011096
	Q96B36
	Q9D1F4
	NM_032375; NM_001098632; NM_001098633; NM_001278159; NM_001278160
NM_001253920; NM_001290694; NM_001290695; NM_026270; NM_001382480;
	NM_001382481; NM_001382482; NM_001382483; NM_001382484
	NP_001092102; NP_001092103; NP_001265088; NP_001265089; NP_115751
NP_001240849; NP_001277623; NP_001277624; NP_080546; NP_001369409;
	NP_001369410; NP_001369411; NP_001369412; NP_001369413
	Wikidata
View/Edit Human	View/Edit Mouse

Proline-rich AKT1 substrate 1 (PRAS) is a protein that in humans is encoded by the AKT1S1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000204673 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000011096 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kovacina KS, Park GY, Bae SS, Guzzetta AW, Schaefer E, Birnbaum MJ, Roth RA (Mar 2003). "Identification of a proline-rich Akt substrate as a 14-3-3 binding partner". The Journal of Biological Chemistry. 278 (12): 10189–94. doi:10.1074/jbc.M210837200. PMID 12524439.
^ "Entrez Gene: AKT1S1 AKT1 substrate 1 (proline-rich)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000204673 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000011096 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12524439-5] Kovacina KS, Park GY, Bae SS, Guzzetta AW, Schaefer E, Birnbaum MJ, Roth RA (Mar 2003). "Identification of a proline-rich Akt substrate as a 14-3-3 binding partner". The Journal of Biological Chemistry. 278 (12): 10189–94. doi:10.1074/jbc.M210837200. PMID 12524439.

[entrez-6] "Entrez Gene: AKT1S1 AKT1 substrate 1 (proline-rich)".

[1]

[2]

[3]

[4]

[5]

[6]