ALOX12

ALOX12
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3D3L
Identifiers
Aliases	ALOX12, 12-LOX, 12S-LOX, LOG12, arachidonate 12-lipoxygenase, 12S type
External IDs	OMIM: 152391; MGI: 87998; HomoloGene: 560; GeneCards: ALOX12; OMA:ALOX12 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	7,010,754 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	70,146,179 bp
RNA expression pattern
	Top expressed in
	amniotic fluid; ; buccal mucosa cell; ; monocyte; ; epithelium of esophagus; ; gonad; ; gums; ; vagina; ; oral cavity; ; skin of abdomen; ; skin of leg;
	Top expressed in
	blood; ; efferent ductule; ; conjunctival fornix; ; tibiofemoral joint; ; transitional epithelium of urinary bladder; ; submandibular gland; ; ankle joint; ; lip; ; seminal vesicula; ; spleen;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	hepoxilin A3 synthase activity; iron ion binding; arachidonate 12(S)-lipoxygenase activity; dioxygenase activity; hepoxilin-epoxide hydrolase activity; metal ion binding; protein binding; linoleate 13S-lipoxygenase activity; oxidoreductase activity; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; hydrolase activity;
Cellular component	cytoplasm; cytosol; membrane; sarcolemma; extracellular exosome;
Biological process	linoleic acid metabolic process; positive regulation of cell death; positive regulation of endothelial cell differentiation; establishment of skin barrier; lipoxin A4 biosynthetic process; lipid metabolism; positive regulation of cell migration; lipoxin B4 biosynthetic process; ageing; negative regulation of apoptotic process; negative regulation of platelet aggregation; negative regulation of muscle cell apoptotic process; fatty acid metabolic process; positive regulation of angiogenesis; reactive oxygen species metabolic process; superoxide anion generation; positive regulation of endothelial cell migration; lipoxygenase pathway; hepoxilin biosynthetic process; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of cell growth; positive regulation of gene expression; leukotriene A4 metabolic process; positive regulation of mitochondrial depolarization; fatty acid oxidation; positive regulation of cell population proliferation; positive regulation of apoptotic process; cellular response to lipid; hepoxilin metabolic process; lipoxin metabolic process; positive regulation of cell adhesion; positive regulation of smooth muscle cell proliferation; arachidonic acid metabolic process; long-chain fatty acid biosynthetic process; positive regulation of blood vessel endothelial cell migration; positive regulation of endothelial tube morphogenesis; lipoxin biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	239
	11684
	ENSG00000108839
	ENSMUSG00000000320
	P18054
	P39655
	NM_000697
	NM_007440; NM_001331118
	NP_000688
	NP_001318047; NP_031466
	Wikidata
View/Edit Human	View/Edit Mouse

ALOX12 (EC 1.13.11.31), also known as arachidonate 12-lipoxygenase, 12-lipoxygenase, 12S-Lipoxygenase, 12-LOX, and 12S-LOX is a lipoxygenase-type enzyme that in humans is encoded by the ALOX12 gene which is located along with other lipoyxgenases on chromosome 17p13.3.^[5]^[6] ALOX12 is 75 kilodalton protein composed of 663 amino acids.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000108839 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000320 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Funk CD, Funk LB, FitzGerald GA, Samuelsson B (May 1992). "Characterization of human 12-lipoxygenase genes". Proceedings of the National Academy of Sciences of the United States of America. 89 (9): 3962–6. Bibcode:1992PNAS...89.3962F. doi:10.1073/pnas.89.9.3962. PMC 525611. PMID 1570320.
^ "Entrez Gene: ALOX12 arachidonate 12-lipoxygenase".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000108839 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000320 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1570320-5] Funk CD, Funk LB, FitzGerald GA, Samuelsson B (May 1992). "Characterization of human 12-lipoxygenase genes". Proceedings of the National Academy of Sciences of the United States of America. 89 (9): 3962–6. Bibcode:1992PNAS...89.3962F. doi:10.1073/pnas.89.9.3962. PMC 525611. PMID 1570320.

[6] "Entrez Gene: ALOX12 arachidonate 12-lipoxygenase".

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