AMOTL2

AMOTL2
Identifiers
Aliases	AMOTL2, LCCP, angiomotin like 2
External IDs	OMIM: 614658; MGI: 1929286; HomoloGene: 9420; GeneCards: AMOTL2; OMA:AMOTL2 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	134,375,479 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	102,610,617 bp
RNA expression pattern
	Top expressed in
	amniotic fluid; ; sural nerve; ; lactiferous duct; ; inferior ganglion of vagus nerve; ; right coronary artery; ; renal medulla; ; ventricular zone; ; germinal epithelium; ; synovial joint; ; parietal pleura;
	Top expressed in
	calvaria; ; adrenal gland; ; right lung; ; ankle; ; ventricular zone; ; white adipose tissue; ; stroma of bone marrow; ; vestibular membrane of cochlear duct; ; lip; ; right lung lobe;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; identical protein binding;
Cellular component	recycling endosome; cytosol; endosome; apical plasma membrane; cytoplasmic vesicle; bicellular tight junction;
Biological process	Wnt signaling pathway; hippo signaling; establishment of cell polarity involved in ameboidal cell migration; actin cytoskeleton organization; regulation of cell migration; angiogenesis;
	Sources:Amigo / QuickGO
Orthologs
	51421
	56332
	ENSG00000114019
	ENSMUSG00000032531
	Q9Y2J4
	Q8K371
	NM_001278683; NM_001278685; NM_016201; NM_001363943
	NM_019764
	NP_001265612; NP_001265614; NP_057285; NP_001350872
	NP_062738
	Wikidata
View/Edit Human	View/Edit Mouse

Angiomotin-like protein 2 is a protein that in humans is encoded by the AMOTL2 gene.^[5]

Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motins protein family.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000114019 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032531 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: AMOTL2 angiomotin like 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000114019 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032531 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: AMOTL2 angiomotin like 2".

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