AMPA receptor positive allosteric modulator

Not to be confused with Ampakine.
CX-516, one of the earliest and a prototypical AMPAR PAM. It is a low-impact AMPAR PAM.
Tulrampator (S-47445, CX-1632), a newer and high-impact AMPAR PAM.

AMPA receptor positive allosteric modulators are positive allosteric modulators (PAMs) of the AMPA receptor (AMPR), a type of ionotropic glutamate receptor which mediates most fast synaptic neurotransmission in the central nervous system.[1]

  1. ^ Lee K, Goodman L, Fourie C, Schenk S, Leitch B, Montgomery JM (2016). "AMPA Receptors as Therapeutic Targets for Neurological Disorders". Ion Channels as Therapeutic Targets, Part A. Advances in Protein Chemistry and Structural Biology. Vol. 103. pp. 203–61. doi:10.1016/bs.apcsb.2015.10.004. ISBN 9780128047941. PMID 26920691. {{cite book}}: |journal= ignored (help)