ANGPT2

ANGPT2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Z3S, 1Z3U, 2GY7, 4JZC, 4ZFG
Identifiers
Aliases	ANGPT2, AGPT2, ANG2, angiopoietin 2, LMPHM10
External IDs	OMIM: 601922; MGI: 1202890; HomoloGene: 22401; GeneCards: ANGPT2; OMA:ANGPT2 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	6,563,409 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	18,791,578 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; popliteal artery; ; tibial arteries; ; placenta; ; islet of Langerhans; ; visceral pleura; ; subcutaneous adipose tissue; ; pericardium; ; internal globus pallidus; ; buccal mucosa cell;
	Top expressed in
	gastrula; ; endothelial cell of lymphatic vessel; ; decidua; ; lumbar spinal ganglion; ; external carotid artery; ; internal carotid artery; ; ascending aorta; ; umbilical cord; ; stroma of kidney; ; stroma of bone marrow;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	metal ion binding; signaling receptor binding; protein binding; receptor tyrosine kinase binding;
Cellular component	cell projection; nucleus; plasma membrane; extracellular region; extracellular space;
Biological process	angiogenesis; response to hypoxia; response to mechanical stimulus; negative regulation of positive chemotaxis; response to radiation; negative regulation of cell-substrate adhesion; signal transduction; animal organ regeneration; response to activity; Tie signaling pathway; cellular response to growth factor stimulus; multicellular organism development; maternal process involved in female pregnancy; negative regulation of angiogenesis; response to organic cyclic compound; leukocyte migration; negative regulation of blood vessel endothelial cell migration; blood vessel morphogenesis; germ cell development; positive regulation of angiogenesis; response to glucose; cell differentiation; glomerulus vasculature development;
	Sources:Amigo / QuickGO
Orthologs
	285
	11601
	ENSG00000091879
	ENSMUSG00000031465
	O15123
	O35608
NM_001147; NM_001118887; NM_001118888; NM_001386335; NM_001386336;
	NM_001386337
	NM_007426
	NP_001112359; NP_001112360; NP_001138
	NP_031452
	Wikidata
View/Edit Human	View/Edit Mouse

Angiopoietin-2 is a protein that in humans is encoded by the ANGPT2 gene.^[5]

Naturally occurring antagonist for both ANGPT1 and TIE2; expressed only at the sites of vascular remodeling; similar to angiopoietin-1^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000091879 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031465 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cheung AH, Stewart RJ, Marsden PA (March 1998). "Endothelial Tie2/Tek ligands angiopoietin-1 (ANGPT1) and angiopoietin-2 (ANGPT2): regional localization of the human genes to 8q22.3-q23 and 8p23". Genomics. 48 (3): 389–91. doi:10.1006/geno.1997.5207. PMID 9545648.
^ "Entrez Gene: ANGPT2 angiopoietin 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000091879 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031465 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9545648-5] Cheung AH, Stewart RJ, Marsden PA (March 1998). "Endothelial Tie2/Tek ligands angiopoietin-1 (ANGPT1) and angiopoietin-2 (ANGPT2): regional localization of the human genes to 8q22.3-q23 and 8p23". Genomics. 48 (3): 389–91. doi:10.1006/geno.1997.5207. PMID 9545648.

[6] "Entrez Gene: ANGPT2 angiopoietin 2".

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