ANGPTL3

ANGPTL3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	6EUA
Identifiers
Aliases	ANGPTL3, ANG-5, ANGPT5, ANL3, FHBL2, angiopoietin like 3
External IDs	OMIM: 604774; MGI: 1353627; HomoloGene: 8499; GeneCards: ANGPTL3; OMA:ANGPTL3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	62,606,313 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	98,934,348 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; kidney tubule; ; metanephric glomerulus; ; human kidney; ; testicle; ; gonad; ; buccal mucosa cell; ; Achilles tendon; ; epithelium of colon; ; stomach;
	Top expressed in
	left lobe of liver; ; fetal liver hematopoietic progenitor cell; ; right kidney; ; human fetus; ; tail of embryo; ; sexually immature organism; ; blastocyst; ; human kidney; ; embryo; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phospholipase inhibitor activity; enzyme inhibitor activity; integrin binding; growth factor activity; heparin binding;
Cellular component	Golgi apparatus; cell surface; early endosome; cell projection; lamellipodium; extracellular region; extracellular space;
Biological process	phospholipid homeostasis; positive regulation of cell migration; positive regulation of lipid catabolic process; lipid storage; cholesterol metabolic process; fatty acid metabolic process; positive regulation of angiogenesis; artery morphogenesis; lipid homeostasis; phospholipid catabolic process; integrin-mediated signaling pathway; negative regulation of lipoprotein lipase activity; response to hormone; phospholipid metabolic process; cholesterol homeostasis; acylglycerol homeostasis; cell-matrix adhesion; glycerol metabolic process; negative regulation of phospholipase activity; triglyceride homeostasis; signal transduction; lipid metabolism; cell adhesion; angiogenesis; regulation of lipoprotein lipase activity; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	27329
	30924
	ENSG00000132855
	ENSMUSG00000028553
	Q9Y5C1
	Q9R182
	NM_014495
	NM_013913
	NP_055310
	NP_038941
	Wikidata
View/Edit Human	View/Edit Mouse

Angiopoietin-like 3, also known as ANGPTL3, is a protein that in humans is encoded by the ANGPTL3 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000132855 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028553 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: ANGPTL3 angiopoietin-like 3".
^ Conklin D, Gilbertson D, Taft DW, Maurer MF, Whitmore TE, Smith DL, et al. (December 1999). "Identification of a mammalian angiopoietin-related protein expressed specifically in liver". Genomics. 62 (3): 477–82. doi:10.1006/geno.1999.6041. PMID 10644446. S2CID 16567474.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000132855 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028553 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: ANGPTL3 angiopoietin-like 3".

[pmid10644446-6] Conklin D, Gilbertson D, Taft DW, Maurer MF, Whitmore TE, Smith DL, et al. (December 1999). "Identification of a mammalian angiopoietin-related protein expressed specifically in liver". Genomics. 62 (3): 477–82. doi:10.1006/geno.1999.6041. PMID 10644446. S2CID 16567474.

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