ANGPTL4

ANGPTL4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	6EUB, 6U0A, 6U1U, 6U73
Identifiers
Aliases	ANGPTL4, ANGPTL2, ARP4, FIAF, HARP, HFARP, NL2, PGAR, TGQTL, UNQ171, pp1158, angiopoietin like 4
External IDs	OMIM: 604774, 605910; MGI: 1888999; HomoloGene: 10755; GeneCards: ANGPTL4; OMA:ANGPTL4 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	8,374,370 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	34,000,804 bp
RNA expression pattern
	Top expressed in
	pericardium; ; beta cell; ; sural nerve; ; subcutaneous adipose tissue; ; right lobe of liver; ; vena cava; ; saphenous vein; ; body of pancreas; ; gastric mucosa; ; cartilage tissue;
	Top expressed in
	brown adipose tissue; ; white adipose tissue; ; tunica adventitia of aorta; ; left lobe of liver; ; subcutaneous adipose tissue; ; lactiferous gland; ; external carotid artery; ; mesenteric lymph nodes; ; right lung lobe; ; proximal tubule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	enzyme inhibitor activity; protein binding; identical protein binding;
Cellular component	extracellular region; blood microparticle; extracellular space;
Biological process	multicellular organism development; negative regulation of lipoprotein lipase activity; cell differentiation; negative regulation of endothelial cell apoptotic process; negative regulation of apoptotic process; response to hypoxia; protein homooligomerization; angiogenesis; triglyceride homeostasis; positive regulation of angiogenesis; regulation of lipid metabolic process; lipid metabolism;
	Sources:Amigo / QuickGO
Orthologs
	51129
	57875
	ENSG00000167772
	ENSMUSG00000002289
	Q9BY76
	Q9Z1P8
	NM_001039667; NM_016109; NM_139314
	NM_020581
	NP_001034756; NP_647475
	NP_065606
	Wikidata
View/Edit Human	View/Edit Mouse

Angiopoietin-like 4 is a protein that in humans is encoded by the ANGPTL4 gene.^[5]^[6]^[7] Alternatively spliced transcript variants encoded with different isoforms have been described. This gene was previously referred to as ANGPTL2, HFARP, PGAR, or FIAF but has been renamed ANGPTL4.

This gene is induced under hypoxic (low oxygen) condition in various cell types and is the target of peroxisome proliferator-activated receptors. The encoded protein is a serum hormone directly involved in regulating lipid metabolism.

ANGPTL4 plays an important role in numerous cancers and is implicated in the metastatic process by modulating vascular permeability, cancer cell motility and invasiveness.^[8]^[9]^[10]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000167772 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002289 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kim I, Kim HG, Kim H, Kim HH, Park SK, Uhm CS, et al. (March 2000). "Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis". The Biochemical Journal. 346 (Pt 3): 603–10. doi:10.1042/0264-6021:3460603. PMC 1220891. PMID 10698685.
^ Yoon JC, Chickering TW, Rosen ED, Dussault B, Qin Y, Soukas A, et al. (July 2000). "Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation". Molecular and Cellular Biology. 20 (14): 5343–9. doi:10.1128/MCB.20.14.5343-5349.2000. PMC 85983. PMID 10866690.
^ Kersten S, Mandard S, Tan NS, Escher P, Metzger D, Chambon P, et al. (September 2000). "Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene" (PDF). The Journal of Biological Chemistry. 275 (37): 28488–93. doi:10.1074/jbc.M004029200. PMID 10862772.
^ Padua D, Zhang XH, Wang Q, Nadal C, Gerald WL, Gomis RR, et al. (April 2008). "TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4". Cell. 133 (1): 66–77. doi:10.1016/j.cell.2008.01.046. PMC 2390892. PMID 18394990.
^ Kim SH, Park YY, Kim SW, Lee JS, Wang D, DuBois RN (November 2011). "ANGPTL4 induction by prostaglandin E2 under hypoxic conditions promotes colorectal cancer progression". Cancer Research. 71 (22): 7010–20. doi:10.1158/0008-5472.CAN-11-1262. PMC 3217078. PMID 21937683.
^ Adhikary T, Brandt DT, Kaddatz K, Stockert J, Naruhn S, Meissner W, et al. (October 2013). "Inverse PPARβ/δ agonists suppress oncogenic signaling to the ANGPTL4 gene and inhibit cancer cell invasion". Oncogene. 32 (44): 5241–52. doi:10.1038/onc.2012.549. PMC 3938163. PMID 23208498.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000167772 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002289 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10698685-5] Kim I, Kim HG, Kim H, Kim HH, Park SK, Uhm CS, et al. (March 2000). "Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis". The Biochemical Journal. 346 (Pt 3): 603–10. doi:10.1042/0264-6021:3460603. PMC 1220891. PMID 10698685.

[pmid10866690-6] Yoon JC, Chickering TW, Rosen ED, Dussault B, Qin Y, Soukas A, et al. (July 2000). "Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation". Molecular and Cellular Biology. 20 (14): 5343–9. doi:10.1128/MCB.20.14.5343-5349.2000. PMC 85983. PMID 10866690.

[pmid10862772-7] Kersten S, Mandard S, Tan NS, Escher P, Metzger D, Chambon P, et al. (September 2000). "Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene" (PDF). The Journal of Biological Chemistry. 275 (37): 28488–93. doi:10.1074/jbc.M004029200. PMID 10862772.

[pmid18394990-8] Padua D, Zhang XH, Wang Q, Nadal C, Gerald WL, Gomis RR, et al. (April 2008). "TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4". Cell. 133 (1): 66–77. doi:10.1016/j.cell.2008.01.046. PMC 2390892. PMID 18394990.

[pmid21937683-9] Kim SH, Park YY, Kim SW, Lee JS, Wang D, DuBois RN (November 2011). "ANGPTL4 induction by prostaglandin E2 under hypoxic conditions promotes colorectal cancer progression". Cancer Research. 71 (22): 7010–20. doi:10.1158/0008-5472.CAN-11-1262. PMC 3217078. PMID 21937683.

[pmid23208498-10] Adhikary T, Brandt DT, Kaddatz K, Stockert J, Naruhn S, Meissner W, et al. (October 2013). "Inverse PPARβ/δ agonists suppress oncogenic signaling to the ANGPTL4 gene and inhibit cancer cell invasion". Oncogene. 32 (44): 5241–52. doi:10.1038/onc.2012.549. PMC 3938163. PMID 23208498.

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