AOC3

AOC3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1PU4, 1US1, 2C10, 2C11, 2Y73, 2Y74, 3ALA, 4BTW, 4BTX, 4BTY
Identifiers
Aliases	AOC3, HPAO, SSAO, VAP-1, VAP1, amine oxidase, copper containing 3, amine oxidase copper containing 3
External IDs	OMIM: 603735; MGI: 1306797; HomoloGene: 2770; GeneCards: AOC3; OMA:AOC3 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	42,858,130 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	101,232,764 bp
RNA expression pattern
	Top expressed in
	saphenous vein; ; superficial temporal artery; ; right lung; ; popliteal artery; ; tibial arteries; ; right coronary artery; ; left coronary artery; ; lower lobe of lung; ; Descending thoracic aorta; ; ascending aorta;
	Top expressed in
	white adipose tissue; ; ascending aorta; ; brown adipose tissue; ; lactiferous gland; ; subcutaneous adipose tissue; ; aortic valve; ; tunica adventitia of aorta; ; tunica media of zone of aorta; ; intercostal muscle; ; umbilical cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; protein homodimerization activity; quinone binding; aliphatic-amine oxidase activity; metal ion binding; tryptamine:oxygen oxidoreductase (deaminating) activity; protein binding; protein heterodimerization activity; oxidoreductase activity; phenethylamine:oxygen oxidoreductase (deaminating) activity; copper ion binding; aminoacetone:oxygen oxidoreductase(deaminating) activity; primary amine oxidase activity;
Cellular component	cytoplasm; integral component of membrane; Golgi apparatus; membrane; plasma membrane; microvillus; cell surface; early endosome; endoplasmic reticulum;
Biological process	response to antibiotic; amine metabolic process; cell adhesion; xenobiotic metabolic process; inflammatory response; negative regulation of primary amine oxidase activity;
	Sources:Amigo / QuickGO
Orthologs
	8639
	11754
	ENSG00000131471
	ENSMUSG00000019326
	Q16853
	O70423
	NM_001277731; NM_001277732; NM_003734
	NM_009675
	NP_001264660; NP_001264661; NP_003725
	NP_033805
	Wikidata
View/Edit Human	View/Edit Mouse

Amine oxidase, copper containing 3 (AOC3), also known as vascular adhesion protein (VAP-1) and HPAO is an enzyme that in humans is encoded by the AOC3 gene on chromosome 17. This protein is a member of the semicarbazide-sensitive amine oxidase (SSAO; aka primary amine oxidase) family of enzymes and is associated with many vascular diseases.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000131471 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019326 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: AOC3 Amine oxidase, copper containing 3".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000131471 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019326 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: AOC3 Amine oxidase, copper containing 3".

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