AP-1 transcription factor

Crystal structure of c-Fos:c-Jun heterodimer and DNA complex (PDB: 1FOS​). In the "Leucine zipper" domain (gray), the hydrophobic residues on c-Fos and hydrophobic residues on c-Jun pack together on the interface of the coiled-coil (leucines are colored in blue, and the other hydrophobic residues are colored in yellow). Residues from the "basic region" (purple) directly interact with the DNA (red).
AP-1 Proteins (Fos, ATF, JDP)
Identifiers
SymbolAP-1
InterProIPR000837
Transcription factor Jun
Identifiers
SymbolLeuzip_Jun
InterProIPR002112

Activator protein 1 (AP-1) is a transcription factor that regulates gene expression in response to a variety of stimuli, including cytokines, growth factors, stress, and bacterial and viral infections.[1] AP-1 controls a number of cellular processes including differentiation, proliferation, and apoptosis.[2] The structure of AP-1 is a heterodimer composed of proteins belonging to the c-Fos, c-Jun, ATF and JDP families.

  1. ^ Hess J, Angel P, Schorpp-Kistner M (December 2004). "AP-1 subunits: quarrel and harmony among siblings". Journal of Cell Science. 117 (Pt 25): 5965–73. doi:10.1242/jcs.01589. PMID 15564374.
  2. ^ Ameyar M, Wisniewska M, Weitzman JB (August 2003). "A role for AP-1 in apoptosis: the case for and against". Biochimie. 85 (8): 747–52. doi:10.1016/j.biochi.2003.09.006. PMID 14585541.