AP-7 (drug)

AP-7
Names
	Preferred IUPAC name 2-Amino-7-phosphonoheptanoic acid
Identifiers
CAS Number	85797-13-3 ;
3D model (JSmol)	Interactive image; Interactive image;
ChEMBL	ChEMBL274440 ;
ChemSpider	3010 ;
PubChem CID	3122;
UNII	P34K80CUSM ;
CompTox Dashboard (EPA)	DTXSID501017823 DTXSID101000167, DTXSID501017823 ;
	InChI InChI=1S/C7H16NO5P/c8-6(7(9)10)4-2-1-3-5-14(11,12)13/h6H,1-5,8H2,(H,9,10)(H2,11,12,13) Key: MYDMWESTDPJANS-UHFFFAOYSA-N ; InChI=1/C7H16NO5P/c8-6(7(9)10)4-2-1-3-5-14(11,12)13/h6H,1-5,8H2,(H,9,10)(H2,11,12,13);
	SMILES O=P(O)(O)CCCCCC(N)C(=O)O; O=P(O)(O)CCCCCC(C(=O)O)N;
Properties
Chemical formula	C7H16NO5P
Molar mass	225.179 g/mol
Density	1.39 g/mL
Boiling point	480.1 °C (896.2 °F; 753.2 K)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

AP-7 is a selective NMDA receptor (NMDAR) antagonist that competitively inhibits the glutamate binding site and thus activation of NMDAR. It has anticonvulsant effects.^[1]

AP-7 functions specifically as a NMDA recognition site blocker, in contrast with 7-chlorokynurenate, which acts as a glycine site modulation blocker.^[2]

^ Meldrum B, Millan M, Patel S, de Sarro G (1988). "Anti-epileptic effects of focal micro-injection of excitatory amino acid antagonists". J. Neural Transm. 72 (3): 191–200. doi:10.1007/BF01243419. PMID 3047315. S2CID 6216838.
^ Guillemin GJ (April 2012). "Quinolinic acid, the inescapable neurotoxin". FEBS J. 279 (8): 1356–65. doi:10.1111/j.1742-4658.2012.08485.x. PMID 22248144. S2CID 205884904.

[pmid3047315-1] Meldrum B, Millan M, Patel S, de Sarro G (1988). "Anti-epileptic effects of focal micro-injection of excitatory amino acid antagonists". J. Neural Transm. 72 (3): 191–200. doi:10.1007/BF01243419. PMID 3047315. S2CID 6216838.

[pmid22248144-2] Guillemin GJ (April 2012). "Quinolinic acid, the inescapable neurotoxin". FEBS J. 279 (8): 1356–65. doi:10.1111/j.1742-4658.2012.08485.x. PMID 22248144. S2CID 205884904.

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