AP2B1

AP2B1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1E42, 2G30, 2IV8, 2IV9, 2JKR, 2JKT, 2VGL, 2XA7, 4UQI
Identifiers
Aliases	AP2B1, ADTB2, AP105B, AP2-BETA, CLAPB1, adaptor related protein complex 2 beta 1 subunit, adaptor related protein complex 2 subunit beta 1
External IDs	OMIM: 601025; MGI: 1919020; HomoloGene: 68176; GeneCards: AP2B1; OMA:AP2B1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	35,726,413 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	83,295,861 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; Brodmann area 10; ; islet of Langerhans; ; stromal cell of endometrium; ; rectum; ; right frontal lobe; ; cingulate gyrus; ; anterior cingulate cortex; ; C1 segment;
	Top expressed in
	spermatid; ; seminiferous tubule; ; spermatocyte; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; lateral septal nucleus; ; tail of embryo; ; cerebellar cortex; ; somite; ; subiculum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	clathrin adaptor activity; protein-containing complex binding; clathrin binding; signal sequence binding; protein binding; cargo receptor activity;
Cellular component	endocytic vesicle membrane; cytosol; clathrin-coated endocytic vesicle membrane; membrane; clathrin coat; plasma membrane; trans-Golgi network; endolysosome membrane; membrane coat; clathrin-coated pit; clathrin adaptor complex; AP-2 adaptor complex; clathrin-coated endocytic vesicle; postsynapse; glutamatergic synapse;
Biological process	cardiac septum development; endocytosis; ventricular septum development; antigen processing and presentation of exogenous peptide antigen via MHC class II; ephrin receptor signaling pathway; mitigation of host defenses by virus; coronary vasculature development; aorta development; heart development; clathrin-dependent endocytosis; clathrin coat assembly; protein transport; intracellular protein transport; vesicle-mediated transport; microtubule-based movement; Wnt signaling pathway, planar cell polarity pathway; membrane organization; neurotransmitter receptor internalization; low-density lipoprotein particle receptor catabolic process; low-density lipoprotein particle clearance; transport; positive regulation of endocytosis; postsynaptic neurotransmitter receptor internalization; negative regulation of neuron death; positive regulation of protein localization to membrane;
	Sources:Amigo / QuickGO
Orthologs
	163
	71770
	ENSG00000006125
	ENSMUSG00000035152
	P63010
	Q9DBG3
	NM_001030006; NM_001282
	NM_001035854; NM_027915
	NP_001025177; NP_001273
	NP_001030931; NP_082191
	Wikidata
View/Edit Human	View/Edit Mouse

AP-2 complex subunit beta is a protein that in humans is encoded by the AP2B1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000006125 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035152 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gallusser A, Kirchhausen T (Dec 1993). "The beta 1 and beta 2 subunits of the AP complexes are the clathrin coat assembly components". The EMBO Journal. 12 (13): 5237–44. doi:10.1002/j.1460-2075.1993.tb06219.x. PMC 413789. PMID 8262066.
^ Druck T, Gu Y, Prabhala G, Cannizzaro LA, Park SH, Huebner K, Keen JH (Nov 1995). "Chromosome localization of human genes for clathrin adaptor polypeptides AP2 beta and AP50 and the clathrin-binding protein, VCP". Genomics. 30 (1): 94–7. doi:10.1006/geno.1995.0016. PMID 8595912.
^ "Entrez Gene: AP2B1 adaptor-related protein complex 2, beta 1 subunit".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000006125 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035152 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8262066-5] Gallusser A, Kirchhausen T (Dec 1993). "The beta 1 and beta 2 subunits of the AP complexes are the clathrin coat assembly components". The EMBO Journal. 12 (13): 5237–44. doi:10.1002/j.1460-2075.1993.tb06219.x. PMC 413789. PMID 8262066.

[pmid8595912-6] Druck T, Gu Y, Prabhala G, Cannizzaro LA, Park SH, Huebner K, Keen JH (Nov 1995). "Chromosome localization of human genes for clathrin adaptor polypeptides AP2 beta and AP50 and the clathrin-binding protein, VCP". Genomics. 30 (1): 94–7. doi:10.1006/geno.1995.0016. PMID 8595912.

[entrez-7] "Entrez Gene: AP2B1 adaptor-related protein complex 2, beta 1 subunit".

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