AP2M1

AP2M1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1H6E, 2JKT, 2JKR, 2VGL, 2BP5
Identifiers
Aliases	AP2M1, AP50, CLAPM1, mu2, adaptor related protein complex 2 mu 1 subunit, adaptor related protein complex 2 subunit mu 1, MRD60
External IDs	OMIM: 601024; MGI: 1298405; HomoloGene: 3000; GeneCards: AP2M1; OMA:AP2M1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	184,184,214 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	20,363,659 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; prefrontal cortex; ; right hemisphere of cerebellum; ; right adrenal gland; ; right adrenal cortex; ; stromal cell of endometrium; ; left adrenal gland; ; left adrenal cortex; ; cingulate gyrus; ; ganglionic eminence;
	Top expressed in
	primary visual cortex; ; Cortex of frontal lobe; ; olfactory bulb; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; neural layer of retina; ; neural tube; ; mesencephalon; ; hippocampus proper; ; hypothalamus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	lipid binding; clathrin adaptor activity; transporter activity; transmembrane transporter binding; protein binding; signal sequence binding; low-density lipoprotein particle receptor binding;
Cellular component	extracellular exosome; lysosomal membrane; AP-2 adaptor complex; endocytic vesicle membrane; cytosol; membrane; endolysosome membrane; clathrin adaptor complex; clathrin-coated pit; clathrin-coated endocytic vesicle membrane; plasma membrane; clathrin-coated endocytic vesicle;
Biological process	ephrin receptor signaling pathway; mitigation of host defenses by virus; clathrin-dependent endocytosis; negative regulation of protein localization to plasma membrane; antigen processing and presentation of exogenous peptide antigen via MHC class II; endocytosis; protein transport; vesicle-mediated transport; intracellular protein transport; Wnt signaling pathway, planar cell polarity pathway; microtubule-based movement; membrane organization; low-density lipoprotein particle receptor catabolic process; low-density lipoprotein particle clearance; transport; vesicle budding from membrane; receptor internalization; regulation of vesicle size;
	Sources:Amigo / QuickGO
Orthologs
	1173
	11773
	ENSG00000161203
	ENSMUSG00000022841
	Q96CW1
	P84091
	NM_004068; NM_001025205; NM_001311198
	NM_009679; NM_001302970
	NP_001020376; NP_001298127; NP_004059
	NP_001289899; NP_033809
	Wikidata
View/Edit Human	View/Edit Mouse

AP-2 complex subunit mu is a protein that in humans is encoded by the AP2M1 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000161203 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022841 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Druck T, Gu Y, Prabhala G, Cannizzaro LA, Park SH, Huebner K, Keen JH (Nov 1995). "Chromosome localization of human genes for clathrin adaptor polypeptides AP2 beta and AP50 and the clathrin-binding protein, VCP". Genomics. 30 (1): 94–7. doi:10.1006/geno.1995.0016. PMID 8595912.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000161203 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022841 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8595912-5] Druck T, Gu Y, Prabhala G, Cannizzaro LA, Park SH, Huebner K, Keen JH (Nov 1995). "Chromosome localization of human genes for clathrin adaptor polypeptides AP2 beta and AP50 and the clathrin-binding protein, VCP". Genomics. 30 (1): 94–7. doi:10.1006/geno.1995.0016. PMID 8595912.

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