| APC internal ribosome entry site (IRES) | |
|---|---|
&sq=&lang=&file=File:RF00462.jpg) Predicted secondary structure and sequence conservation of IRES_APC | |
| Identifiers | |
| Symbol | IRES_APC |
| Rfam | RF00462 |
| Other data | |
| RNA type | Cis-reg; IRES |
| Domain(s) | Eukaryota |
| GO | GO:0043022 |
| SO | SO:0000243 |
| PDB structures | PDBe |
The APC internal ribosome entry site (IRES) is an RNA element which is located in the coding sequence of the APC gene. APC is a tumour suppressor gene which is associated with the inherited disease adenomatous polyposis coli (APC). It is thought that IRES-mediated translation of APC is important for an apoptotic cascade.[1]
- ^ Heppner Goss K, Trzepacz C, Tuohy TM, Groden J (June 2002). "Attenuated APC alleles produce functional protein from internal translation initiation". Proceedings of the National Academy of Sciences of the United States of America. 99 (12): 8161–8166. doi:10.1073/pnas.112072199. PMC 123038. PMID 12034871.