ARG2

ARG2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1PQ3, 4HZE, 4I06, 4IE2, 4IE3, 4IXU, 4IXV
Identifiers
Aliases	ARG2, arginase 2
External IDs	OMIM: 107830; MGI: 1330806; HomoloGene: 906; GeneCards: ARG2; OMA:ARG2 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	67,651,708 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	79,203,075 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; oocyte; ; renal medulla; ; human kidney; ; secondary oocyte; ; islet of Langerhans; ; pituitary gland; ; beta cell; ; mucosa of paranasal sinus; ; anterior pituitary;
	Top expressed in
	duodenum; ; granulocyte; ; primary oocyte; ; lobe of prostate; ; jejunum; ; zygote; ; transitional epithelium of urinary bladder; ; hair follicle; ; secondary oocyte; ; intestinal villus;
	More reference expression data
	n/a
Gene ontology
Molecular function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines; arginase activity; hydrolase activity; metal ion binding; manganese ion binding;
Cellular component	mitochondrial matrix; mitochondrion; cytoplasm;
Biological process	urea cycle; ureteric bud development; nitric oxide biosynthetic process; striated muscle contraction; arginine metabolic process; negative regulation of type 2 immune response; negative regulation of tumor necrosis factor production; negative regulation of macrophage inflammatory protein 1 alpha production; negative regulation of chemokine (C-C motif) ligand 4 production; negative regulation of chemokine (C-C motif) ligand 5 production; negative regulation of defense response to bacterium; regulation of reactive oxygen species biosynthetic process; negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process; negative regulation of CD4-positive, alpha-beta T cell proliferation; positive regulation of cellular senescence; adaptive immune response; immune system process; innate immune response; arginine catabolic process to ornithine;
	Sources:Amigo / QuickGO
Orthologs
	384
	11847
	ENSG00000081181
	ENSMUSG00000021125
	P78540
	O08691
	NM_001172
	NM_009705
	NP_001163
	NP_033835
	Wikidata
View/Edit Human	View/Edit Mouse

Arginase, type II is an arginase protein that in humans is encoded by the ARG2 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000081181 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021125 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Arginase, type II".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000081181 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021125 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Arginase, type II".

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