ARHGAP26

ARHGAP26
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UGV
Identifiers
Aliases	ARHGAP26, GRAF, GRAF1, OPHN1L, OPHN1L1, Rho GTPase activating protein 26
External IDs	OMIM: 605370; MGI: 1918552; HomoloGene: 36349; GeneCards: ARHGAP26; OMA:ARHGAP26 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	143,229,011 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	39,509,337 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; blood; ; epithelium of colon; ; monocyte; ; right uterine tube; ; testicle; ; granulocyte; ; bone marrow cells; ; Achilles tendon; ; postcentral gyrus;
	Top expressed in
	interventricular septum; ; lobe of cerebellum; ; cerebellar vermis; ; zygote; ; otolith organ; ; utricle; ; prefrontal cortex; ; subiculum; ; anterior amygdaloid area; ; visual cortex;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; phospholipid binding; GTPase activator activity;
Cellular component	cytoplasm; cytosol; cell junction; cytoskeleton; focal adhesion; cellular component;
Biological process	regulation of small GTPase mediated signal transduction; actin cytoskeleton organization; nervous system development; signal transduction; positive regulation of GTPase activity;
	Sources:Amigo / QuickGO
Orthologs
	23092
	71302
	ENSG00000145819
	ENSMUSG00000036452
	Q9UNA1
	Q6ZQ82
	NM_001135608; NM_015071; NM_001349547
	NM_175164; NM_001361073; NM_001374831
	NP_001129080; NP_055886; NP_001336476
	NP_780373; NP_001348002; NP_001361760
	Wikidata
View/Edit Human	View/Edit Mouse

Rho GTPase activating protein 26 (ARHGAP26) also known as GTPase Regulator Associated with Focal Adhesion Kinase (GRAF) is a protein that in humans is encoded by the ARHGAP26 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000145819 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036452 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: ARHGAP26 Rho GTPase activating protein 26".
^ Hildebrand JD, Taylor JM, Parsons JT (June 1996). "An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase". Mol. Cell. Biol. 16 (6): 3169–78. doi:10.1128/MCB.16.6.3169. PMC 231310. PMID 8649427.
^ Taylor JM, Macklem MM, Parsons JT (January 1999). "Cytoskeletal changes induced by GRAF, the GTPase regulator associated with focal adhesion kinase, are mediated by Rho". J. Cell Sci. 112 (2): 231–42. doi:10.1242/jcs.112.2.231. PMID 9858476.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000145819 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036452 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: ARHGAP26 Rho GTPase activating protein 26".

[pmid8649427-6] Hildebrand JD, Taylor JM, Parsons JT (June 1996). "An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase". Mol. Cell. Biol. 16 (6): 3169–78. doi:10.1128/MCB.16.6.3169. PMC 231310. PMID 8649427.

[pmid9858476-7] Taylor JM, Macklem MM, Parsons JT (January 1999). "Cytoskeletal changes induced by GRAF, the GTPase regulator associated with focal adhesion kinase, are mediated by Rho". J. Cell Sci. 112 (2): 231–42. doi:10.1242/jcs.112.2.231. PMID 9858476.

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