ARHGEF9

ARHGEF9
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2YSQ
Identifiers
Aliases	ARHGEF9, COLLYBISTIN, EIEE8, HPEM-2, PEM-2, PEM2, Cdc42 guanine nucleotide exchange factor 9, DEE8
External IDs	OMIM: 300429; MGI: 2442233; HomoloGene: 9053; GeneCards: ARHGEF9; OMA:ARHGEF9 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	63,809,274 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	94,240,462 bp
RNA expression pattern
	Top expressed in
	Brodmann area 46; ; prefrontal cortex; ; Region I of hippocampus proper; ; nucleus accumbens; ; lateral nuclear group of thalamus; ; parietal lobe; ; superior frontal gyrus; ; postcentral gyrus; ; right frontal lobe; ; dorsolateral prefrontal cortex;
	Top expressed in
	superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; olfactory tubercle; ; piriform cortex; ; primary motor cortex; ; cerebellar cortex; ; lateral septal nucleus; ; hippocampus proper; ; globus pallidus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	guanyl-nucleotide exchange factor activity;
Cellular component	cytoplasm; cytosol; postsynaptic density; GABA-ergic synapse; plasma membrane; membrane; cell junction; synapse; postsynaptic membrane;
Biological process	positive regulation of apoptotic process; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; G protein-coupled receptor signaling pathway; regulation of postsynaptic specialization assembly;
	Sources:Amigo / QuickGO
Orthologs
	23229
	236915
	ENSG00000131089
	ENSMUSG00000025656
	O43307
	Q3UTH8
NM_001173479; NM_001173480; NM_015185; NM_001330495; NM_001353921;
	NM_001353922; NM_001353923; NM_001353924; NM_001353926; NM_001353927; NM_001353928; NM_001369030; NM_001369031; NM_001369032; NM_001369033; NM_001369034; NM_001369035; NM_001369036; NM_001369037; NM_001369038; NM_001369039; NM_001369040; NM_001369041; NM_001369042; NM_001369043; NM_001369044; NM_001369045
	NM_001033329; NM_001290384; NM_001290385
NP_001166950; NP_001166951; NP_001317424; NP_056000; NP_001340850;
	NP_001340851; NP_001340852; NP_001340853; NP_001340855; NP_001340856; NP_001340857; NP_001355959; NP_001355960; NP_001355961; NP_001355962; NP_001355963; NP_001355964; NP_001355965; NP_001355966; NP_001355967; NP_001355968; NP_001355969; NP_001355970; NP_001355971; NP_001355972; NP_001355973; NP_001355974
NP_001028501; NP_001277313; NP_001277314; NP_001392830; NP_001392831;
	NP_001392832; NP_001392833; NP_001392834; NP_001392835; NP_001392836; NP_001392837; NP_001392838; NP_001392839; NP_001392840; NP_001392841; NP_001392842; NP_001392843; NP_001392844; NP_001392845; NP_001392846; NP_001392847
	Wikidata
View/Edit Human	View/Edit Mouse

Rho guanine nucleotide exchange factor 9 is a protein that in humans is encoded by the ARHGEF9 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000131089 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025656 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Reid T, Bathoorn A, Ahmadian MR, Collard JG (Dec 1999). "Identification and characterization of hPEM-2, a guanine nucleotide exchange factor specific for Cdc42". J Biol Chem. 274 (47): 33587–93. doi:10.1074/jbc.274.47.33587. PMID 10559246.
^ Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
^ Cite error: The named reference entrez was invoked but never defined (see the help page).

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000131089 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025656 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10559246-5] Reid T, Bathoorn A, Ahmadian MR, Collard JG (Dec 1999). "Identification and characterization of hPEM-2, a guanine nucleotide exchange factor specific for Cdc42". J Biol Chem. 274 (47): 33587–93. doi:10.1074/jbc.274.47.33587. PMID 10559246.

[pmid9455477-6] Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.

[entrez-7] Cite error: The named reference entrez was invoked but never defined (see the help page).

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