AS04

Adjuvant System 04 or AS04 is a trade name for a combination of adjuvants used in various vaccine products by GlaxoSmithKline,[1] in particular the Fendrix[2] hepatitis B vaccine and Cervarix[3] human papillomavirus (HPV) vaccine. It consists of aluminium hydroxide and monophosphoryl lipid A (MPL). It is the successor of AS03, a squalene based adjuvant used in H1N1/09 and H5N1 influenza vaccines.[4][5][6][7]

  1. ^ "Vaccine Adjuvant System Technology Background Information" (PDF). Archived from the original (PDF) on 2009-01-05.
  2. ^ "Products | GSKpro". Archived from the original on 2013-03-04.
  3. ^ "Products | GSKpro". Archived from the original on 2009-05-29.
  4. ^ Ellis, Ronald W.; Rappuoli, Rino; Ahmed, Sohail (2013). "Technologies for making new vaccines". In Plotkin, Stanley A.; Orenstein, Walter A.; Offit, Paul A. (eds.). Vaccines (Sixth ed.). W.B. Saunders. pp. 1182–1199. doi:10.1016/B978-1-4557-0090-5.00013-6. ISBN 9781455700905.
  5. ^ Garçon, Nathalie; Van Mechelen, Marcelle; Wettendorff, Martine (2006). "Development and evaluation of AS04, a novel and improved adjuvant system containing MPL and aluminum salt". Immunopotentiators in Modern Vaccines. pp. 161–177. doi:10.1016/B978-012088403-2/50011-3. ISBN 9780120884032.
  6. ^ Laupèze, Béatrice; Hervé, Caroline; Di Pasquale, Alberta; Tavares Da Silva, Fernanda (2019). "Adjuvant Systems for vaccines: 13 years of post-licensure experience in diverse populations have progressed the way adjuvanted vaccine safety is investigated and understood". Vaccine. 37 (38): 5670–5680. doi:10.1016/j.vaccine.2019.07.098. PMID 31420171. S2CID 201042219.
  7. ^ Garçon, N.; Di Pasquale, A. (2016). "From discovery to licensure, the Adjuvant System story". Human Vaccines & Immunotherapeutics. 13 (1): 19–33. doi:10.1080/21645515.2016.1225635. PMC 5287309. PMID 27636098.