ATF3

ATF3
Identifiers
Aliases	ATF3, activating transcription factor 3
External IDs	OMIM: 603148; MGI: 109384; HomoloGene: 1265; GeneCards: ATF3; OMA:ATF3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	212,620,777 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	190,950,236 bp
RNA expression pattern
	Top expressed in
	vena cava; ; gastric mucosa; ; gallbladder; ; saphenous vein; ; trachea; ; urethra; ; pericardium; ; skin of thigh; ; left uterine tube; ; cardia;
	Top expressed in
	granulocyte; ; plantaris muscle; ; lumbar spinal ganglion; ; islet of Langerhans; ; intestinal villus; ; jejunum; ; muscle of thigh; ; stroma of bone marrow; ; sciatic nerve; ; endocardial cushion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transcription cis-regulatory region binding; protein homodimerization activity; protein binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein heterodimerization activity; identical protein binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA binding; transcription corepressor activity; DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleolus; nucleoplasm; CHOP-ATF3 complex; nucleus;
Biological process	regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; positive regulation of cell population proliferation; skeletal muscle cell differentiation; regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance; gluconeogenesis; cellular response to amino acid starvation; negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; positive regulation of TRAIL-activated apoptotic signaling pathway; transcription, DNA-templated; positive regulation of gene expression; PERK-mediated unfolded protein response; positive regulation of transcription by RNA polymerase II; negative regulation of ERK1 and ERK2 cascade; negative regulation of transcription by RNA polymerase II; endoplasmic reticulum unfolded protein response; transcription by RNA polymerase II; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	467
	11910
	ENSG00000162772
	ENSMUSG00000026628
	P18847
	Q60765
NM_001030287; NM_001040619; NM_001206484; NM_001206485; NM_001206486;
	NM_001206488; NM_001674; NM_004024
	NM_007498
NP_001025458; NP_001035709; NP_001193413; NP_001193415; NP_001193417;
	NP_001665
	NP_031524
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclic AMP-dependent transcription factor ATF-3 is a protein that, in humans, is encoded by the ATF3 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000162772 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026628 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chen BP, Liang G, Whelan J, Hai T (June 1994). "ATF3 and ATF3 delta Zip. Transcriptional repression versus activation by alternatively spliced isoforms". The Journal of Biological Chemistry. 269 (22): 15819–26. doi:10.1016/S0021-9258(17)40754-X. PMID 7515060.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000162772 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026628 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7515060-5] Chen BP, Liang G, Whelan J, Hai T (June 1994). "ATF3 and ATF3 delta Zip. Transcriptional repression versus activation by alternatively spliced isoforms". The Journal of Biological Chemistry. 269 (22): 15819–26. doi:10.1016/S0021-9258(17)40754-X. PMID 7515060.

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