ATF4

ATF4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CI6
Identifiers
Aliases	ATF4, CREB-2, CREB2, TAXREB67, TXREB, activating transcription factor 4
External IDs	OMIM: 604064; MGI: 88096; HomoloGene: 1266; GeneCards: ATF4; OMA:ATF4 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.1 Start 39,519,695 bp[1] End 39,522,683 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 E1|15 37.85 cM Start 80,139,385 bp[2] End 80,141,742 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle layer of sigmoid colon popliteal artery tibial arteries body of stomach subcutaneous adipose tissue fundus right coronary artery body of pancreas left coronary artery Descending thoracic aorta Top expressed in ankle joint calvaria fetal liver hematopoietic progenitor cell granulocyte lacrimal gland plantaris muscle temporal muscle islet of Langerhans triceps brachii muscle muscle of thigh More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding sequence-specific DNA binding DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific transcription factor binding RNA polymerase II cis-regulatory region sequence-specific DNA binding core promoter sequence-specific DNA binding protein C-terminus binding protein binding leucine zipper domain binding protein heterodimerization activity protein kinase binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding Cellular component cytoplasm ATF1-ATF4 transcription factor complex ATF4-CREB1 transcription factor complex transcription regulator complex dendrite membrane nucleus Lewy body core nuclear periphery membrane plasma membrane nucleoplasm microtubule organizing center neuron projection cytoskeleton CHOP-ATF4 complex centrosome protein-containing complex RNA polymerase II transcription regulator complex Biological process gamma-aminobutyric acid signaling pathway gluconeogenesis regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress regulation of transcription by RNA polymerase II negative regulation of oxidative stress-induced neuron death cellular response to amino acid starvation mRNA transcription by RNA polymerase II circadian regulation of gene expression response to endoplasmic reticulum stress PERK-mediated unfolded protein response response to manganese-induced endoplasmic reticulum stress positive regulation of transcription, DNA-templated positive regulation of neuron apoptotic process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress positive regulation of gene expression positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress circadian rhythm negative regulation of potassium ion transport positive regulation of transcription by RNA polymerase II positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance cellular response to glucose starvation negative regulation of translational initiation in response to stress rhythmic process cellular response to UV positive regulation of transcription from RNA polymerase II promoter in response to stress cellular amino acid metabolic process transcription by RNA polymerase II transcription, DNA-templated positive regulation of apoptotic process positive regulation of vascular endothelial growth factor production positive regulation of transcription by RNA polymerase I cellular response to dopamine response to toxic substance neuron differentiation cellular response to oxygen-glucose deprivation positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway cellular calcium ion homeostasis positive regulation of biomineral tissue development negative regulation of cold-induced thermogenesis positive regulation of vascular associated smooth muscle cell apoptotic process positive regulation of sodium-dependent phosphate transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 468 11911 Ensembl ENSG00000128272 ENSMUSG00000042406 UniProt P18848 Q06507 RefSeq (mRNA) NM_182810 NM_001675 NM_001287180 NM_009716 RefSeq (protein) NP_001666 NP_877962 NP_001274109 NP_033846 Location (UCSC) Chr 22: 39.52 – 39.52 Mb Chr 15: 80.14 – 80.14 Mb PubMed search [3] [4]
Wikidata
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Activating transcription factor 4 (tax-responsive enhancer element B67), also known as ATF4, is a protein that in humans is encoded by the ATF4 gene.^[5][6]