ATG16L1

ATG16L1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4GDK, 4GDL, 4NAW, 4TQ0, 5D7G
Identifiers
Aliases	ATG16L1, autophagy related 16-like 1 (S. cerevisiae), APG16L, ATG16A, ATG16L, IBD10, WDR30, autophagy related 16 like 1
External IDs	OMIM: 610767; MGI: 1924290; HomoloGene: 41786; GeneCards: ATG16L1; OMA:ATG16L1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.1 Start 233,210,051 bp[1] End 233,295,674 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 D Start 87,683,592 bp[2] End 87,720,150 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum testicle gonad granulocyte right frontal lobe right lobe of thyroid gland left lobe of thyroid gland skin of leg gastrocnemius muscle skin of abdomen Top expressed in neural layer of retina secondary oocyte primary oocyte granulocyte motor neuron superior frontal gyrus primary visual cortex right ventricle transitional epithelium of urinary bladder dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquitin-like protein transferase activity protein binding identical protein binding GTPase binding Cellular component cytoplasm autophagosome axoneme cytosol phagophore assembly site membrane autophagosome membrane membrane Biological process protein transport autophagy negative stranded viral RNA replication protein homooligomerization macroautophagy autophagosome assembly protein localization to phagophore assembly site protein lipidation involved in autophagosome assembly xenophagy positive regulation of autophagy Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55054 77040 Ensembl ENSG00000281089 ENSG00000085978 ENSMUSG00000026289 UniProt Q676U5 Q8C0J2 RefSeq (mRNA) NM_001190266 NM_001190267 NM_017974 NM_030803 NM_198890 NM_001363742 NM_001205391 NM_001205392 NM_029846 RefSeq (protein) NP_001177195 NP_001177196 NP_060444 NP_110430 NP_942593 NP_001350671 NP_060444.3 NP_001192320 NP_001192321 NP_084122 Location (UCSC) Chr 2: 233.21 – 233.3 Mb Chr 1: 87.68 – 87.72 Mb PubMed search [3] [4]
Wikidata
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Autophagy related 16 like 1 is a protein that in humans is encoded by the ATG16L1 gene.^[5] This protein is characterized as a subunit of the autophagy-related ATG12-ATG5/ATG16 complex and is essentially important for the LC3 (ATG8) lipidation and autophagosome formation. This complex localizes to the membrane and is released just before or after autophagosome completion.^[6]

Furthermore, ATG16L1 appears to have other autophagy-independent functions, e.g., intracellular membrane trafficking regulation and inflammation.^[6] Autophagy in general plays a crucial role in pathways leading to innate and adaptive immunity activation.^[7] That is why many autophagy-related proteins, including ATG16L1, their gene expression and its role in autoimmune diseases are studied in-depth nowadays.^[when?]