| autophagy related protein 8 | |||||||
|---|---|---|---|---|---|---|---|
 The crystal structure of microtubule-associated protein light chain 3, a mammalian homologue of Saccharomyces cerevisiae Atg8.[1] | |||||||
| Identifiers | |||||||
| Organism | |||||||
| Symbol | Atg8 | ||||||
| Alt. symbols | Apg8, Aut7, Cvt5 | ||||||
| Entrez | 852200 | ||||||
| RefSeq (mRNA) | NM_001178318 | ||||||
| RefSeq (Prot) | NP_009475 | ||||||
| UniProt | P38182 | ||||||
| Other data | |||||||
| Chromosome | VII: 0.16 - 0.16 Mb | ||||||
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Autophagy-related protein 8 (Atg8) is a ubiquitin-like protein required for the formation of autophagosomal membranes. The transient conjugation of Atg8 to the autophagosomal membrane through a ubiquitin-like conjugation system is essential for autophagy in eukaryotes. Even though there are homologues in animals (see for example GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B, MAP1LC3B2, and MAP1LC3C), this article mainly focuses on its role in lower eukaryotes such as Saccharomyces cerevisiae.
- ^ PDB: 1UGM; Sugawara K, Suzuki NN, Fujioka Y, Mizushima N, Ohsumi Y, Inagaki F (July 2004). "The crystal structure of microtubule-associated protein light chain 3, a mammalian homologue of Saccharomyces cerevisiae Atg8". Genes to Cells. 9 (7): 611–8. doi:10.1111/j.1356-9597.2004.00750.x. PMID 15265004.