ATOX1

ATOX1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesATOX1, ATX1, HAH1, antioxidant 1 copper chaperone
External IDsOMIM: 602270; MGI: 1333855; HomoloGene: 2984; GeneCards: ATOX1; OMA:ATOX1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

475

11927

Ensembl

ENSG00000177556

ENSMUSG00000018585

UniProt

O00244

O08997

RefSeq (mRNA)

NM_004045

NM_009720

RefSeq (protein)

NP_004036

NP_033850

Location (UCSC)Chr 5: 151.74 – 151.77 MbChr 11: 55.34 – 55.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ATOX1 is a copper metallochaperone protein that is encoded by the ATOX1 gene in humans.[5][6] In mammals, ATOX1 plays a key role in copper homeostasis as it delivers copper from the cytosol to transporters ATP7A and ATP7B.[7][8][9] Homologous proteins are found in a wide variety of eukaryotes, including Saccharomyces cerevisiae as ATX1, and all contain a conserved metal binding domain.[7][10]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000177556 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018585 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Cite error: The named reference Klomp 1997 was invoked but never defined (see the help page).
  6. ^ Cite error: The named reference entrez was invoked but never defined (see the help page).
  7. ^ a b Cite error: The named reference Bertini 2006 was invoked but never defined (see the help page).
  8. ^ Cite error: The named reference Banci 2013 was invoked but never defined (see the help page).
  9. ^ Cite error: The named reference Maret 2014 was invoked but never defined (see the help page).
  10. ^ Cite error: The named reference Boal 2009 was invoked but never defined (see the help page).