ATP-dependent Clp protease proteolytic subunit

CLPP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1TG6
Identifiers
Aliases	CLPP, PRLTS3, DFNB81, caseinolytic mitochondrial matrix peptidase proteolytic subunit
External IDs	OMIM: 601119; MGI: 1858213; HomoloGene: 4385; GeneCards: CLPP; OMA:CLPP - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	6,370,242 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	57,303,188 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; gastrocnemius muscle; ; mucosa of transverse colon; ; apex of heart; ; right adrenal gland; ; left adrenal gland; ; right adrenal cortex; ; right lobe of liver; ; left adrenal cortex; ; body of stomach;
	Top expressed in
	interventricular septum; ; right kidney; ; facial motor nucleus; ; morula; ; morula; ; condyle; ; blastocyst; ; right ventricle; ; adrenal gland; ; otic placode;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; serine-type peptidase activity; serine-type endopeptidase activity; protein binding; hydrolase activity; identical protein binding; ATP-dependent peptidase activity; ATPase binding;
Cellular component	mitochondrial matrix; mitochondrion; endopeptidase Clp complex;
Biological process	proteolysis involved in cellular protein catabolic process; protein homooligomerization; proteolysis; protein quality control for misfolded or incompletely synthesized proteins;
	Sources:Amigo / QuickGO
Orthologs
	8192
	53895
	ENSG00000125656
	ENSMUSG00000002660
	Q16740
	O88696
	NM_006012
	NM_017393
	NP_006003
	NP_059089
	Wikidata
View/Edit Human	View/Edit Mouse

ATP-dependent Clp protease proteolytic subunit (ClpP) is an enzyme that in humans is encoded by the CLPP gene.^[5]^[6] This protein is an essential component to form the protein complex of Clp protease (Endopeptidase Clp).

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125656 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002660 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bross P, Andresen BS, Knudsen I, Kruse TA, Gregersen N (December 1995). "Human ClpP protease: cDNA sequence, tissue-specific expression and chromosomal assignment of the gene". FEBS Letters. 377 (2): 249–252. doi:10.1016/0014-5793(95)01353-9. PMID 8543061. S2CID 22019074.
^ "Entrez Gene: CLPP ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000125656 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002660 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8543061-5] Bross P, Andresen BS, Knudsen I, Kruse TA, Gregersen N (December 1995). "Human ClpP protease: cDNA sequence, tissue-specific expression and chromosomal assignment of the gene". FEBS Letters. 377 (2): 249–252. doi:10.1016/0014-5793(95)01353-9. PMID 8543061. S2CID 22019074.

[entrez-6] "Entrez Gene: CLPP ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli)".

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