AUC may refer to:
- Ab urbe condita or Anno urbis conditae, Latin for "from the founding of the city" (of Rome), used for dates
- African Union Commission, the executive/administrative branch or secretariat of the supranational organisation
- Ammonium uranyl carbonate, a chemical compound used in uranium processing
- Appropriate use criteria for a medical procedure or service
- Area under the curve (receiver operating characteristic), a performance measure for binary classifiers
- Area under the curve (pharmacokinetics), regarding plasma drug concentration-time curves
- Authentication Center in a GSM mobile phone network
- United Self-Defense Forces of Colombia (Spanish: Autodefensas Unidas de Colombia), former Colombian paramilitary and drugs group
- Santiago Pérez Quiroz Airport, Arauca, Colombia, IATA code
- Analytical ultracentrifugation, Physical and biophysical chemistry instrument
- a codon for the amino acid isoleucine