AVP gene

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Structures	Swiss-model
Domains	InterPro

preproAVP
preproAVP
	Diagram of the pre-pro-AVP precursor showing position and size in amino acids of vasopressin, neurophysin II and copeptin
Identifiers
Symbol	preproAVP
OMIM	192340
UniProt	P01185
Other data
Locus	Chr. 20 p13
Structures
Search for
Structures	Swiss-model
Domains	InterPro

AVP
Identifiers
Aliases	AVP, ADH, ARVP, AVP-NPII, AVRP, VP, AVP gene, AVP (gene), Prepro-AVP-NP II, arginine vasopressin gene, vasopressin gene, prepro-arginine-vasopressin-neurophysin II gene, vasopressin-neurophysin II-copeptin, vasopressin-neurophysin 2-copeptin, prepro-AVP2
External IDs	OMIM: 192340; MGI: 88121; HomoloGene: 417; GeneCards: AVP; OMA:AVP - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	3,084,724 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	130,424,474 bp
RNA expression pattern
	Top expressed in
	hypothalamus; ; internal globus pallidus; ; gastric mucosa; ; apex of heart; ; human kidney; ; monocyte; ; left testis; ; amygdala; ; anterior pituitary; ; right adrenal cortex;
	Top expressed in
	paraventricular nucleus of hypothalamus; ; supraoptic nucleus; ; arcuate nucleus; ; optic nerve; ; median eminence; ; suprachiasmatic nucleus; ; nucleus of stria terminalis; ; ventromedial nucleus; ; lateral hypothalamus; ; hair;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein kinase activity; hormone activity; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; neurohypophyseal hormone activity; signaling receptor binding; V1A vasopressin receptor binding; V1B vasopressin receptor binding; neuropeptide hormone activity;
Cellular component	extracellular region; cytosol; clathrin-coated vesicle membrane; extracellular space; secretory granule; dendrite;
Biological process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; vasoconstriction; negative regulation of release of cytochrome c from mitochondria; ERK1 and ERK2 cascade; water transport; cell-cell signaling; negative regulation of apoptotic process; protein kinase C signaling; generation of precursor metabolites and energy; positive regulation of peptidyl-serine phosphorylation; positive regulation of gene expression; renal water homeostasis; signal transduction; apoptotic process; membrane organization; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; maternal aggressive behavior; positive regulation of systemic arterial blood pressure; positive regulation of cytosolic calcium ion concentration; negative regulation of female receptivity; grooming behavior; locomotory behavior; positive regulation of cell population proliferation; positive regulation of glutamate secretion; response to organic cyclic compound; positive regulation of cell growth; positive regulation of prostaglandin biosynthetic process; positive regulation of cellular pH reduction; response to testosterone; response to nicotine; social behavior; regulation of renal sodium excretion; hyperosmotic salinity response; maternal behavior; penile erection; response to ethanol; positive regulation of vasoconstriction; multicellular organismal water homeostasis; negative regulation of transmission of nerve impulse;
	Sources:Amigo / QuickGO
Orthologs
	551
	11998
	ENSG00000101200
	ENSMUSG00000037727
	P01185
	P35455
	NM_000490
	NM_009732
	NP_000481
	NP_033862
	Wikidata
View/Edit Human	View/Edit Mouse

The arginine vasopressin (AVP) gene is a gene whose product is proteolytically cleaved to produce vasopressin (also known as antidiuretic hormone or ADH), neurophysin II, and a glycoprotein called copeptin. AVP and other AVP-like peptides are found in mammals, as well as mollusks, arthropods, nematodes, and other invertebrate species.^[5] In humans, AVP is present on chromosome 20 and plays a role in homeostatic regulation. The products of AVP have many functions that include vasoconstriction, regulating the balance of water in the body, and regulating responses to stress.^[6] Expression of AVP is regulated by the transcription translation feedback loop (TTFL), which is an important part of the circadian system that controls the expression of clock genes. AVP has important implications in the medical field as its products have significant roles throughout body.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000101200 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037727 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Albers HE (January 2015). "Species, sex and individual differences in the vasotocin/vasopressin system: relationship to neurochemical signaling in the social behavior neural network". Frontiers in Neuroendocrinology. 36: 49–71. doi:10.1016/j.yfrne.2014.07.001. PMC 4317378. PMID 25102443.
^ Ryckmans T (September 2010). "Modulation of the vasopressin system for the treatment of CNS diseases". Current Opinion in Drug Discovery & Development. 13 (5): 538–47. PMID 20812145.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000101200 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037727 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Albers HE (January 2015). "Species, sex and individual differences in the vasotocin/vasopressin system: relationship to neurochemical signaling in the social behavior neural network". Frontiers in Neuroendocrinology. 36: 49–71. doi:10.1016/j.yfrne.2014.07.001. PMC 4317378. PMID 25102443.

[6] Ryckmans T (September 2010). "Modulation of the vasopressin system for the treatment of CNS diseases". Current Opinion in Drug Discovery & Development. 13 (5): 538–47. PMID 20812145.

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