AZD1305

AZD1305
Names
	IUPAC name 2-Methyl-2-propanyl (2-{7-[2-(4-cyano-2-fluorophenoxy)ethyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}ethyl)carbamate
Identifiers
CAS Number	872045-91-5 ;
3D model (JSmol)	Interactive image;
ChemSpider	13080567;
ECHA InfoCard	100.170.290
PubChem CID	15605092;
UNII	CZO834LXQM ;
CompTox Dashboard (EPA)	DTXSID701030144 ;
	InChI InChI=1S/C22H31FN4O4/c1-22(2,3)31-21(28)25-6-7-26-12-17-14-27(15-18(13-26)30-17)8-9-29-20-5-4-16(11-24)10-19(20)23/h4-5,10,17-18H,6-9,12-15H2,1-3H3,(H,25,28) Key: BLLNYXOLLAVTRF-UHFFFAOYSA-N; InChI=1/C22H31FN4O4/c1-22(2,3)31-21(28)25-6-7-26-12-17-14-27(15-18(13-26)30-17)8-9-29-20-5-4-16(11-24)10-19(20)23/h4-5,10,17-18H,6-9,12-15H2,1-3H3,(H,25,28) Key: BLLNYXOLLAVTRF-UHFFFAOYAY;
	SMILES O=C(OC(C)(C)C)NCCN1CC2OC(C1)CN(C2)CCOc3ccc(C#N)cc3F;
Properties
Chemical formula	C22H31FN4O4
Molar mass	434.512 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

AZD1305 is an experimental drug candidate that is under investigation for the management and reversal of cardiac arrhythmias, specifically atrial fibrillation and flutter. In vitro studies have shown that this combined-ion channel blocker inhibits rapidly the activating delayed-rectifier potassium current (IKr), L-type calcium current, and inward sodium current (INa).^[1]

^ Sicouri, S.; Carlsson, L.; Antzelevitch, C. (2010). "Electrophysiologic and Antiarrhythmic Effects of AZD1305 in Canine Pulmonary Vein Sleeves". Journal of Pharmacology and Experimental Therapeutics. 334 (1): 255–9. doi:10.1124/jpet.110.166702. PMC 2912040. PMID 20360353.

[Sicouri-1] Sicouri, S.; Carlsson, L.; Antzelevitch, C. (2010). "Electrophysiologic and Antiarrhythmic Effects of AZD1305 in Canine Pulmonary Vein Sleeves". Journal of Pharmacology and Experimental Therapeutics. 334 (1): 255–9. doi:10.1124/jpet.110.166702. PMC 2912040. PMID 20360353.

[1]