Abecarnil

Abecarnil
Clinical data
ATC code
  • none
Pharmacokinetic data
Elimination half-life3.4 hours (IV), 7 hours (oral)
Identifiers
  • propan-2-yl 4-(methoxymethyl)-6-(phenylmethoxy) -9H-pyrido[5,4-b]indole-3-carboxylate
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC24H24N2O4
Molar mass404.466 g·mol−1
3D model (JSmol)
  • COCc3c(C(=O)OC(C)C)ncc4[nH]c2ccc(OCc1ccccc1)cc2c34
  • InChI=1S/C24H24N2O4/c1-15(2)30-24(27)23-19(14-28-3)22-18-11-17(29-13-16-7-5-4-6-8-16)9-10-20(18)26-21(22)12-25-23/h4-12,15,26H,13-14H2,1-3H3 checkY
  • Key:RLFKILXOLJVUNF-UHFFFAOYSA-N checkY
  (verify)

Abecarnil (ZK-112,119) is an anxiolytic drug from the β-Carboline family. It is one of a relatively recently developed class of medicines known as the nonbenzodiazepines, which have similar effects to the older benzodiazepine group, but with quite different chemical structures. It is a partial agonist acting selectively at the benzodiazepine site of the GABAA receptor.[1]

  1. ^ Ozawa M, Nakada Y, Sugimachi K, Yabuuchi F, Akai T, Mizuta E, et al. (March 1994). "Pharmacological characterization of the novel anxiolytic beta-carboline abecarnil in rodents and primates". Japanese Journal of Pharmacology. 64 (3): 179–187. doi:10.1254/jjp.64.179. PMID 7912751.