Acebutolol

Acebutolol
Clinical data
Trade names	Sectral, Prent, others
AHFS/Drugs.com	Monograph
MedlinePlus	a687003
License data	US FDA: Acebutolol;
Pregnancy; category	AU: C; ;
Routes of; administration	By mouth, IV
ATC code	C07AB04 (WHO) ;
Legal status
Legal status	UK: POM (Prescription only); In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	40% (range 35 to 50%)
Metabolism	Hepatic
Elimination half-life	3-4 hours (parent drug); 8-13 hours (active metabolite)
Excretion	Renal: 30%; Biliary: 60%
Identifiers
	IUPAC name (RS)-N-{3-acetyl-4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}butanamide;
CAS Number	37517-30-9 ;
PubChem CID	1978;
IUPHAR/BPS	7107;
DrugBank	DB01193 ;
ChemSpider	1901 ;
UNII	67P356D8GH;
KEGG	D02338 ;
ChEBI	CHEBI:2379 ;
ChEMBL	ChEMBL642 ;
CompTox Dashboard (EPA)	DTXSID2048539 ;
ECHA InfoCard	100.048.654
Chemical and physical data
Formula	C18H28N2O4
Molar mass	336.432 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	121 °C (250 °F)
	SMILES O=C(Nc1ccc(OCC(O)CNC(C)C)c(c1)C(=O)C)CCC;
	InChI InChI=1S/C18H28N2O4/c1-5-6-18(23)20-14-7-8-17(16(9-14)13(4)21)24-11-15(22)10-19-12(2)3/h7-9,12,15,19,22H,5-6,10-11H2,1-4H3,(H,20,23) ; Key:GOEMGAFJFRBGGG-UHFFFAOYSA-N ;
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Acebutolol,^[1] sold under the brand names Sectral among others, is a beta blocker for the treatment of hypertension and arrhythmias. Acebutolol is a cardioselective beta-1 blocker and has intrinsic sympathetic activity. It is commonly used in the treatment of angina.

It was patented in 1967 and approved for medical use in 1973.^[2]

^ Elks J, Ganellin CR (1990). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 2–. ISBN 978-1-4757-2085-3.
^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 461. ISBN 9783527607495.

[1] Elks J, Ganellin CR (1990). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 2–. ISBN 978-1-4757-2085-3.

[2] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 461. ISBN 9783527607495.

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