Clinical data | |
---|---|
Trade names | Atravet, Acezine 2 |
AHFS/Drugs.com | International Drug Names |
Routes of administration | IV, IM, SQ, oral[1][2] |
ATC code | |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | 6.6 L/kg, high volume of distribution |
Elimination half-life | 3 hours in horses, 15.9 hours in canines |
Excretion | urine |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.000.451 |
Chemical and physical data | |
Formula | C19H22N2OS |
Molar mass | 326.46 g·mol−1 |
3D model (JSmol) | |
| |
| |
(verify) |
Acepromazine, acetopromazine, or acetylpromazine (commonly known as ACP, Ace, or by the trade names Atravet or Acezine 2, number depending on mg/ml dose) is a phenothiazine derivative antipsychotic drug. It was used in humans during the 1950s as an antipsychotic,[4] but is now almost exclusively used on animals as a sedative and antiemetic. A closely related analogue, chlorpromazine, is still used in humans.
The standard pharmaceutical preparation, acepromazine maleate, is used in veterinary medicine in dogs and cats. It is used widely in horses as a pre-anesthetic sedative and has been shown to reduce anesthesia related death.[5] However, it should be used with caution (but is not absolutely contraindicated) in stallions due to the risk of paraphimosis and priapism.[6] Its potential for cardiac effects can be profound, namely hypotension due to peripheral vasodilation, so it should be avoided or used with caution in geriatric or debilitated animals.[7]
Dugdale 2016
was invoked but never defined (see the help page).plumb
was invoked but never defined (see the help page).