Activating transcription factor 2

ATF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BHI, 1T2K, 4H36
Identifiers
Aliases	ATF2, CRE-BP1, CREB-2, CREB2, HB16, TREB7, activating transcription factor 2
External IDs	OMIM: 123811; MGI: 109349; HomoloGene: 31061; GeneCards: ATF2; OMA:ATF2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	175,168,382 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	73,892,639 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; germinal epithelium; ; Brodmann area 23; ; corpus epididymis; ; caput epididymis; ; mucosa of paranasal sinus; ; Pars compacta; ; tail of epididymis; ; ganglionic eminence; ; Epithelium of choroid plexus;
	Top expressed in
	paraventricular nucleus of hypothalamus; ; medial dorsal nucleus; ; dorsomedial hypothalamic nucleus; ; habenula; ; arcuate nucleus; ; ventral tegmental area; ; olfactory tubercle; ; lateral septal nucleus; ; anterior amygdaloid area; ; subiculum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; cAMP response element binding protein binding; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; transcription coactivator activity; chromatin binding; metal ion binding; protein binding; cis-regulatory region sequence-specific DNA binding; nucleic acid binding; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; protein kinase binding; cAMP response element binding; histone acetyltransferase activity; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription factor binding; protein heterodimerization activity;
Cellular component	cytoplasm; membrane; nucleoplasm; mitochondrial outer membrane; mitochondrion; nucleus; site of double-strand break;
Biological process	regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; mitotic intra-S DNA damage checkpoint signaling; outflow tract morphogenesis; response to water deprivation; positive regulation of DNA-binding transcription factor activity; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; positive regulation of transforming growth factor beta2 production; transcription, DNA-templated; cellular response to DNA damage stimulus; response to osmotic stress; positive regulation of neuron apoptotic process; regulation of DNA-binding transcription factor activity; positive regulation of mitochondrial membrane permeability involved in apoptotic process; negative regulation of epithelial cell proliferation; adipose tissue development; fat cell differentiation; positive regulation of transcription by RNA polymerase II; amelogenesis; histone acetylation; positive regulation of cardiac muscle myoblast proliferation; positive regulation of gene expression; negative regulation of angiogenesis;
	Sources:Amigo / QuickGO
Orthologs
	1386
	11909
	ENSG00000115966
	ENSMUSG00000027104
	P15336
	P16951
NM_001256090; NM_001256091; NM_001256092; NM_001256093; NM_001256094;
	NM_001880
NM_001025093; NM_001284369; NM_001284370; NM_001284371; NM_001284372;
	NM_001284373; NM_001284374; NM_001284376; NM_009715
NP_001243019; NP_001243020; NP_001243021; NP_001243022; NP_001243023;
	NP_001871
NP_001020264; NP_001271298; NP_001271299; NP_001271300; NP_001271301;
	NP_001271302; NP_001271303; NP_001271305; NP_033845
	Wikidata
View/Edit Human	View/Edit Mouse

Activating transcription factor 2, also known as ATF2, is a protein that, in humans, is encoded by the ATF2 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115966 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027104 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: ATF2 activating transcription factor 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115966 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027104 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: ATF2 activating transcription factor 2".

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