Active surveillance of prostate cancer

Active surveillance is a management option for localized prostate cancer that can be offered to appropriate patients who would also be candidates for aggressive local therapies (surgery and radiotherapy), with the intent to intervene if the disease progresses. Active surveillance should not be confused with watchful waiting, another observational strategy for men that would not be candidates for curative therapy (surgery, radiation) because of a limited life expectancy.

Active surveillance offers men with a prostate cancer that is thought to have a low risk of causing harm in the absence of treatment, a chance to delay or avoid aggressive treatment and its associated side effects.[citation needed] While prostate cancer is the most common non-cutaneous cancer and second leading cause of cancer-related death in American men, it is conservatively estimated that approximately 100,000 men per year in the United States who would be eligible for conservative treatment through active surveillance, undergo unnecessary treatments. The management of localized prostate cancer is controversial and men with localized disease diagnosed today often undergo treatments with significant side effects that will not improve overall health outcomes.

The 2011 NIH State-of-the-Science Conference Statement on the "Role of active surveillance in the management of men with localized prostate cancer" pointed out the many unanswered questions about observational strategies for prostate cancer that require further research and clarification.[1] These included:

  • Improvements in the accuracy and consistency of pathologic diagnosis of prostate cancer
  • Consensus on which men are the most appropriate candidates for active surveillance
  • The optimal protocol for active surveillance and the potential for individualizing the approach based on clinical and patient factors
  • Optimal ways to communicate the option of active surveillance to patients
  • Methods to assist patient decision-making
  • Reasons for acceptance or rejection of active surveillance as a treatment strategy
  • Short- and long-term outcomes of active surveillance[1]

The consensus statement highlighted the need for well-designed studies to address these questions as an important health research priority. In the meantime, active surveillance for the treatment of low risk prostate cancer is now being offered to more and more patients where it is generally considered that prostate cancer will not cause the man harm during his lifetime if treatment is delayed or avoided. For these men, surveillance is thought to offer a more targeted approach to management; avoiding unnecessary treatment and its risk of associated side effects, while allowing for curative intervention for those that experience disease progression on observation.

  1. ^ a b Ganz, PA; J. M. Barry; W. Burke; N. F. Col; P. S. Corso; E. Dodson; M. E. Hammond; B. A. Kogan; C. F. Lynch; L. Newcomer; E. J. Seifter; J. A. Tooze; K. Viswanath; H. Wessells (2012). "National Institutes of Health State-of-the-Science Conference: role of active surveillance in the management of men with localized prostate cancer". Ann Intern Med. 156 (8): 591–595. doi:10.7326/0003-4819-156-8-201204170-00401. PMC 4774889. PMID 22351514.