Acute myelomonocytic leukemia

Acute myelomonocytic leukemia
SpecialtyHematology, oncology

Acute myelomonocytic leukemia (AMML) is a form of acute myeloid leukemia that involves a proliferation of CFU-GM myeloblasts and monoblasts. AMML occurs with a rapid increase amount in white blood cell count and is defined by more than 20% of myeloblast in the bone marrow. It is classified under "M4" in the French-American-British classification (FAB).[1] It is classified under "AML, not otherwise classified" in the WHO classification.[2]

Translocations have been observed.[3] Progression from myelodysplastic syndrome has been reported.[4]

  1. ^ "Acute Myeloid Leukemia - Signs and Symptoms".
  2. ^ Seiter, Karen (2023-07-26). "Acute Myeloid Leukemia (AML): Practice Essentials, Pathophysiology, Etiology". Medscape Reference. Retrieved 2024-06-26.
  3. ^ Yamamoto K, Nagata K, Tsurukubo Y, et al. (2002). "Translocation (8;12)(q13;p13) during disease progression in acute myelomonocytic leukemia with t(11;19)(q23;p13.1)". Cancer Genet. Cytogenet. 137 (1): 64–7. doi:10.1016/S0165-4608(02)00555-1. PMID 12377416.
  4. ^ Zhang L, Alsabeh R, Mecucci C, et al. (2007). "Rare t(1;11)(q23;p15) in therapy-related myelodysplastic syndrome evolving into acute myelomonocytic leukemia: a case report and review of the literature". Cancer Genet. Cytogenet. 178 (1): 42–8. doi:10.1016/j.cancergencyto.2007.06.012. PMID 17889707.