Acyl carrier protein

Acyl/peptidyl carrier protein
Streptomyces coelicolor actinorhodin polyketide synthase acyl carrier protein - PDB: 2AF8
Identifiers
SymbolACP-like_sf
PfamPF00550
Pfam clanCL0314
InterProIPR036736
PROSITEPDOC00012
CATH1nq4
SCOP21nq4 / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

The acyl carrier protein (ACP) is a cofactor of both fatty acid and polyketide biosynthesis machinery. It is one of the most abundant proteins in cells of E. coli.[1] In both cases, the growing chain is bound to the ACP via a thioester derived from the distal thiol of a 4'-phosphopantetheine moiety.

  1. ^ Cronan, John E. (2014). "The Chain-Flipping Mechanism of ACP (Acyl Carrier Protein)-Dependent enzymes Appears Universal". Biochemical Journal. 460 (2): 157–163. doi:10.1042/BJ20140239. PMID 24825445.