Addressin

MADCAM1
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesMADCAM1, MACAM1, mucosal vascular addressin cell adhesion molecule 1
External IDsOMIM: 102670; GeneCards: MADCAM1; OMA:MADCAM1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_130762
NM_130760

n/a

RefSeq (protein)

NP_570116
NP_570118

n/a

Location (UCSC)Chr 19: 0.49 – 0.51 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) is a protein that in humans is encoded by the MADCAM1 gene.[3][4][5] The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4 / beta7), L-selectin, and VLA-4 (alpha4 / beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin superfamily and is similar to ICAM-1 and VCAM-1.[3]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000099866Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ a b "Entrez Gene: mucosal vascular addressin cell adhesion molecule 1".
  4. ^ Shyjan AM, Bertagnolli M, Kenney CJ, Briskin MJ (April 1996). "Human mucosal addressin cell adhesion molecule-1 (MAdCAM-1) demonstrates structural and functional similarities to the alpha 4 beta 7-integrin binding domains of murine MAdCAM-1, but extreme divergence of mucin-like sequences". Journal of Immunology. 156 (8): 2851–7. doi:10.4049/jimmunol.156.8.2851. PMID 8609404. S2CID 24940438.
  5. ^ Leung E, Berg RW, Langley R, Greene J, Raymond LA, Augustus M, et al. (1997). "Genomic organization, chromosomal mapping, and analysis of the 5' promoter region of the human MAdCAM-1 gene". Immunogenetics. 46 (2): 111–9. doi:10.1007/s002510050249. PMID 9162097. S2CID 9453114.