Adefovir

Adefovir
Clinical data
Trade namesHepsera
AHFS/Drugs.comMonograph
Pregnancy
category
  • AU: B3
Routes of
administration
Oral
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability59%
Protein binding<4%
Elimination half-life7.5 hours
ExcretionUrine
Identifiers
  • {[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}phosphonic acid
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
NIAID ChemDB
CompTox Dashboard (EPA)
ECHA InfoCard100.106.235 Edit this at Wikidata
Chemical and physical data
FormulaC8H12N5O4P
Molar mass273.189 g·mol−1
3D model (JSmol)
  • O=P(O)(O)COCCn1c2ncnc(c2nc1)N
  • InChI=1S/C8H12N5O4P/c9-7-6-8(11-3-10-7)13(4-12-6)1-2-17-5-18(14,15)16/h3-4H,1-2,5H2,(H2,9,10,11)(H2,14,15,16) checkY
  • Key:SUPKOOSCJHTBAH-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Adefovir is a prescription medicine used to treat (chronic) infections with hepatitis B virus. A prodrug form of adefovir was previously called bis-POM PMEA, with trade names Preveon and Hepsera. It is an orally administered nucleotide analog reverse-transcriptase inhibitor (ntRTI). It can be formulated as the pivoxil prodrug adefovir dipivoxil.